Dr. Philipp Voigt
Babraham Institute, Cambridge, UK
“Decoding bivalency: Mechanisms of poising at developmental gene promoters.”
The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).
Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th.
On Wednesday, October 7th at 11:00 am.
Zoom link for remote attendees:
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09
Meeting ID: 861 1442 2072
Secret code: 492809
Relevant publications from the speaker
H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability.
Yuan W, Huang YC, LeBlanc C, Poulet A, De Luna Vitorino FN, Valsakumar D, Dean R, Garcia BA, van Wolfswinkel JC, Voigt P, Jacob Y. Nat Commun. 2025 Apr 14;16(1):3547. doi: 10.1038/s41467-025-58892-2.
Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains.
Bryan E, Valsakumar D, Idigo NJ, Warburton M, Webb KM, McLaughlin KA, Spanos C, Lenci S, Major V, Ambrosi C, Andrews S, Baubec T, Rappsilber J, Voigt P. Mol Cell. 2025 Feb 6;85(3):471-489.e12. doi: 10.1016/j.molcel.2024.12.002.
The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Wapenaar H, Clifford G, Rolls W, Pasquier M, Burdett H, Zhang Y, Deák G, Zou J, Spanos C, Taylor MRD, Mills J, Watson JA, Kumar D, Clark R, Das A, Valsakumar D, Bramham J, Voigt P, Sproul D, Wilson MD. EMBO Rep. 2024 Dec;25(12):5743-5779. doi: 10.1038/s44319-024-00306-3.
Nucleosomal asymmetry: a novel mechanism to regulate nucleosome function.
Valsakumar D, Voigt P. Biochem Soc Trans. 2024 Jun 26;52(3):1219-1232. doi: 10.1042/BST20230877
New research article on how chromatin marking governs DNA damage segregation in mitosis
In this paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis with potential consequences on daughter cell fate. Thus, we reveal that chromatin alterations impinge on genome stability not only by...
Welcome to Julia
Julia Roche Dupuy joined the lab for her second year Master's internship. Julia Roche Dupuy Second year Master's student À lire aussi
Welcome Caroline to our team!
We're excited to have Caroline joining Dr. Ait-si-Ali's team! She comes to us as an M2 student from the GENE2 master's program at Université Paris-Saclay. Working with Dr. Guillaume Velasco, Caroline will study the regulation of nuclear stiffness by H3K9...
Welcome Minh to Slimane Ait-si-ali’s team!
We are delighted to welcome Mynh, an M2 student from the GENE2 master's program at Université Paris-Saclay, to Dr. Ait-si-Ali's team. Mynh will be investigating the role of SETDB1 in Duchenne muscular dystrophy phenotype development.
Welcome to Steve
Today, we welcome a new member to the team: Steve, a M2 student from the Magistère Européen de Génétique and an EUR GENE fellow.Steve will be working on the interactions of recently identified new parasite protein.Read more
New review: X chromosome regulation and female functional specificities: Are two Xs better than one?
What if the presence of two X chromosomes confers functional specificities on female cells and contributes to the different susceptibilites of men and women to certain diseases? One of the X chromosomes is randomly silenced in each female cell from the embryonic...
New review: Genetic diseases of epigenetic machinery
The development of sequencing technologies and their increased accessibility in clinical services and genetic laboratories have considerably accelerated the identification of genetic variants associated with rare diseases. Among these, Mendelian disorders of the...
Congratulations to Guillaume!
Congratulations to Dr Guillaume Velasco on obtaining his Habilitation à Diriger des Recherches (HDR) this Wednesday, December 18th. A well-deserved accomplishment!Jury members: Giséle Bonne, Jean-Charles Cadoret, Fabienne Malagnac and Guillermo OrsiCongratulations,...
Congratulations to Dr. Carole Chaput
Congratulations to Dr. Carole Chaput who defended her thesis this Friday, December 6, 2024 on « Therapeutic functionalization of a rare neurodevelopmental and monogenic disease model based on the contribution of the heat shock factor 2 stress pathway »À lire aussi
Congratulations to Dr. Kevin Daupin
Congratulations to Dr. Kevin Daupin who defended his thesis this Wednesday, December 4, 2024 on « Integrity of Neuroepithelium & the Neural Niche in Rubinstein-Taybi Syndrome Derived Neural Models : A perspective on the implication of HSF2 pathways dysregulations...
Welcome to Megan
Today, we welcome a new member to the team: Megan, a M1 student from the EPHE where she's doing the Integrative Master for Global Health and Ecology, Integrative Physiopathology course.Megan will be working with Souhila on lysine methylation signalling by SMYD2.Read...
New review: Unleashing XIST from X-chromosome inactivation
The discovery that long noncoding RNAs (lncRNAs) are the most abundant gene class in the human genome has sparked significant research, particularly on Xist, a key RNA involved in X-chromosome inactivation. Recent studies have expanded our understanding of Xist's...
Congratulations to Emmanuelle !
Last week, Emmanuelle Ceddaha, one of our PhD student, defended her pharmacy thesis. It was a great presentation which not only earned her the congratulations of the jury, but also the distinction of ‘very good’ (and the unofficial distinction of ‘excellent’) for her...
Happy Birthday EDC !
On 8 October 2024, our unit celebrated it's 15th anniversary but also 15 years of scientific and technical advances.It was a great day, both scientifically and humanly. From left to right : Ariane, Jérémy, Charles, Emmanuelle, Jonathan, Camille (front), Angélique,...
EDC15: Fifteen Years of Epigenetics and Cell Fate
The Epigenetics and Cell Fate Center celebrates its fifteen years of existence on October 8, 2024. Come, and join us for this special day! This conference will look back on 15 years of scientific advances in the fields of epigenetics and cellular differentiation in...
2024 Young Scientists Day
It’s time to create our own network! The 27th of June young scientists from BFA (Biologie Fonctionelle Adaptative), IJM (Institut Jacques Monod) and us (EDC) will meet to share amazing science and create the foundations of future collaborations...
Call for new Research Group Leaders
The Epigenetics and Cell Fate Centre is seeking to recruit two talented junior and/or senior group leaders.Download the call (.pdf) Download the application form (.doc) The Epigenetics and Cell Fate Centre is a leading institute exploring cell identity and...
Congratulations Dr Carrillo
Congratulations to Léo who defended his thesis work on " Exploring the link between X chromosome inactivation and the development of human extraembryonic tissues " . © Rougeulle team À lire aussi
Review on the chromatin-based regulation of genome maintenance
A review from our research group is out for publication in DNA Repair as part of the special issue "Cutting-Edge Perspectives in Genome Maintenance". This review presents our current knowledge on the contribution of pre-existing and DNA damage-induced chromatin marks...
Elphège Nora seminar – June 19, 2024
Wednesday, June 19, 2024, at 11:00 am. Elphège Nora UCSF, San FranciscoInvited by Claire Rougeulle “Molecular mechanisms of chromosome folding and enhancer wiring” The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Buffon building, 15 rue...