Dec 23, 2024 | Epigenetics & Cell Fate, Publications, Rougeulle group
What if the presence of two X chromosomes confers functional specificities on female cells and contributes to the different susceptibilites of men and women to certain diseases? One of the X chromosomes is randomly silenced in each female cell from the embryonic...
Dec 21, 2024 | Ait-Si-Ali group, Publications
New review: Genetic diseases of epigenetic machinery The development of sequencing technologies and their increased accessibility in clinical services and genetic laboratories have considerably accelerated the identification of genetic variants associated with rare...
Jun 11, 2024 | Polo group, Publications
A review from our research group is out for publication in DNA Repair as part of the special issue “Cutting-Edge Perspectives in Genome Maintenance”. This review presents our current knowledge on the contribution of pre-existing and DNA damage-induced...
Jun 5, 2024 | Publications, Rougeulle group
Our latest work carried out by Alfeghaly C. et al. elucidating the mechanism of dampening of X-linked gene expression during pre-implantation development. To discover the role of the long non-coding RNA XIST and its particular partner SPEN click on the link: Nature...
May 6, 2024 | Publications, Rougeulle group
Our latest work by Huret et al. linking X chromosome inactivation to autoimmunity is published in Science Advances This work is discussed in different journals: NewScientist: Autoimmune conditions linked to reactivated X chromosome genes National Geographic: Why women...
Jan 12, 2024 | Polo group, Publications
January 12th 2024: We have uncovered an altered DNA repair activity in H3.3 mutant pediatric high-grade glioma that fosters genome instability independently of previously described oncogenic pathways. Furthermore, we have identified a DNA repair enzyme that sustains...
Sep 8, 2023 | Publications
Congratulations on the new work “ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats” by Grillo et al. shared on bioRxiv. Read here:...
Sep 7, 2023 | Defossez group, Publications
Congratulations to the Defossez team for their paper “A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation” by Yakhou, Azogui, Gupta et al., which was published in Nucleic Acid Research. Read it...
Sep 7, 2023 | Defossez group, Publications
Congratulations to the Defossez group for their paper “A genome-wide screen reveals new regulators of the 2-cell-like cell state” by Gupta, Yakhou et al., published in Nature Structural and Molecular Biology. Read it here: doi:...
Mar 16, 2023 | Defossez group, Publications
Congratulations to Laure and Pierre-Antoine for their collaborative paper accepted in Scientific Reports: “Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1”...
Feb 3, 2023 | Publications, Rougeulle group
Congratulations to the team members for this new article about “Species-specific regulation of XIST by the JPX/FTX orthologs” published in Nucleic Acids Research (Feb 2023). Graphical abstract In contrast to the mouse, human JPX regulates XIST through...
