Vector-GENIE: Vectorology and Genome Engineering in Epigenetics

• • Slimane Ait-Si-Ali
  • Pierre-Antoine Defossez  
  • Aurélie de Thonel  
  • Ekaterina Boyarchuk (Vector-GENIE platforms manager)

•  

• Ekaterina Boyarchuk

  Head, IR CNRS

  Carine Ganem-Elbaz

  IE CNRS

  Laurence Del Maestro

  AI CNRS

2024

•  Richard A.,  Berthelet J.,  Judith D., Advedissian T., Espadas J., Jannot G., Amo A., Loew D.,Lombard B., Casanova AG., Reynoird N.,Roux A., Berlioz-Torrent C., Echard A.,  Weitzman J B. & Medjkane S. Methylation of ESCRT-III components regulates the timing of cytokinetic abscission. Nature Communications 2024 May

2023

• Yakhou L, Azogui A, Gupta N, Richard Albert J, Miura F, Ferry L, Yamaguchi K, Battault S, Therizols P, Bonhomme F, Bethuel E, Sarkar A, Greenberg MVC, Arimondo PB, Cristofari G, Kirsh O, Ito T, Defossez PA0 A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation. Nucleic Acids Res. 2023 Oct

• Gupta N, Yakhou L, Albert JR, Azogui A, Ferry L, Kirsh O, Miura F, Battault S, Yamaguchi K, Laisné M, Domrane C, Bonhomme F, Sarkar A, Delagrange M, Ducos B, Cristofari G, Ito T, Greenberg MVC, Defossez PA. A genome-wide screen reveals new regulators of the 2-cell-like cell state Nat Struct Mol Biol. 2023 Aug

• Rosspopoff O,  Cazottes E, Huret C, Loda A, Collier A, Casanova M, Rugg-Gunn P, Heard E, Ouimette, J-F, Rougeulle C. Species-specific regulation of XIST by the JPX/FTX orthologs . Nucleic Acids Research, 2023 Feb 

2019

• Casanova M, Moscatelli M, Chauvière LÉ, Huret C, Samson J, Liyakat Ali TM, Rosspopoff O, Rougeulle C. A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Nat Commun. 2019 Dec 11;10(1):5652.

• Codato R, Perichon M, Divol A, Fung E, Sotiropoulos A, Bigot A, Weitzman JB, Medjkane S.The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network.  Sci Rep. 2019 Nov 21

• Naciri I,  Laisné M, Ferry L,  Bourmaud M,  Gupta N,   Di Carlo S,  Huna A,  Martin N, Peduto L,  Bernard D,  Kirsh O,  Defossez PA.  Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors. Nucleic Acids Research, 07 February 2019 gkz080, https://doi.org/10.1093/nar/gkz080

2018

• Furlan G, Gutierrez Hernandez N, Huret C, Galupa R, van Bemmel JG, Romito A, Heard E, Morey C, Rougeulle C.  The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products. Mol Cell. 2018 Apr 20. pii: S1097-2765(18)30227-2. 

To contact the Platform

Platform manager: Ekaterina BOYARCHUK  ekaterina.boyarchuk@u-pariscite.fr

Plateforme Vector-GENIE

CNRS UMR 7216, 4e etage

35 Rue Hélène Brion

75013 Paris