BiBs : Bioinformatics and Biostatistics

The Epigenetics and Cell Fate lab BiBs facility provides a broad range of services related to bioinformatics.

We develop and provide standardized protocols for the analysis of NGS data in epigenomics. We support staff in their bioinformatics and biostatistics analyses, promoting their skills development and developing their autonomy. Our services include technology watch, specific analyses, as well as personalized training for our users. We also maintain access to a local compute resource. Finally, an important part of our job is to promote good practices in data analysis and management.
The BiBs platform is part of and actively contributes to the development of the iPOP-UP platform which federates and promotes bioinformatics at the level of the Université Paris Cité.
The facility includes two permanent staff and regularly welcomes trainees or apprentices.

Our expertise is about the analysis of high-throughput sequencing data (Illumina and Oxford Nanopore). We can guide you on analyzing different types of omics data:

• Transcriptome (RNA-seq)
• Methylome (bisulphite sequencing, or direct long-read detection by nanopore)
• Genomic localization of transcription factors or histone marks (ChIP-seq or CUT&RUN)
• Chromatin accessibility (ATAC-seq)
• Chromosome conformation (Hi-C)

In addition to ‘bulk’ analyses, we are strengthening our skills in the analysis of ‘single-cell’ data, in particular thanks to the iPOP-UP network.

We are also experts in the integration of different bioinformatics tools within workflows (Snakemake), which makes analyzes reproducible and accessible to a wide audience of researchers. Our workflows are compatible with the high performance computing clusters of the Université Paris Cité (iPOP-UP, hosted by RPBS) and the French Institute of Bioinformatics.

Finally, we have expertise in data management (drafting of data management plans, FAIR principles).