January 12th 2024: We have uncovered an altered DNA repair activity in H3.3 mutant pediatric high-grade glioma that fosters genome instability independently of previously described oncogenic pathways. Furthermore, we have identified a DNA repair enzyme that sustains the proliferation of cells bearing H3.3 mutations, thus conferring a specific molecular vulnerability with potential for therapeutic targeting. We thank all our collaborators on this work for their great contributions. See Giacomini et al., Nucleic Acids Res, 2024.
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Seminar Jan Padeken –October 14, 2026
Dr. Jan Padeken Institute of Molecular Biology, Mainz, Germany "UV-Damage-induced Epigenetic Memory in Organismal Resilience and Aging." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th....
Seminar Philipp Voigt –October 7, 2026
Dr. Philipp Voigt Babraham Institute, Cambridge, UK "Decoding bivalency: Mechanisms of poising at developmental gene promoters." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th. On...
Congratulations to Dr. Silvia Comunian!
On September 25, 2026, Silvia successfully defended her thesis: “Epigenetic control of nuclear mechanics and migration via H3K9 methylation at Lamina-Associated Domains in lung cancer cells”Silvia Comunian and the jury members: Yegor Vassetzky, Nicolas Borghi,...
Welcome to Sara
Sara is joining the team for a master’s internship. As a student in the Interdisciplinary Master’s in Life Sciences program at the Ecole Normale Superieure, Sara will contribute to a research project aimed at identifying vulnerabilities in DNA repair in high-grade...