January 12th 2024: We have uncovered an altered DNA repair activity in H3.3 mutant pediatric high-grade glioma that fosters genome instability independently of previously described oncogenic pathways. Furthermore, we have identified a DNA repair enzyme that sustains the proliferation of cells bearing H3.3 mutations, thus conferring a specific molecular vulnerability with potential for therapeutic targeting. We thank all our collaborators on this work for their great contributions. See Giacomini et al., Nucleic Acids Res, 2024.
À lire aussi
Congratulations to Dr. Silvia Comunian!
On September 25, 2026, Silvia successfully defended her thesis: “Epigenetic control of nuclear mechanics and migration via H3K9 methylation at Lamina-Associated Domains in lung cancer cells”Silvia Comunian and the jury members: Yegor Vassetzky, Nicolas Borghi,...
Welcome to Sara
Sara is joining the team for a master’s internship. As a student in the Interdisciplinary Master’s in Life Sciences program at the Ecole Normale Superieure, Sara will contribute to a research project aimed at identifying vulnerabilities in DNA repair in high-grade...
Seminar Cristiano SIMONE –September 30, 2026
Dr. Cristiano SIMONE University of Bari Aldo Moro, Bari, ItalyInvited by Dr. Souhila MEDJKANE "Unraveling SMYD3 functions along the Cancer Hallmark trail." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène...
Seminar Charles Williams –September 23, 2026
Dr. Charles Williams MRC Centre for Regenerative Medicine, The University of Edinburgh Invited by Dr. Dounia DJEGHLOUL "Mitotic bookmarking and chromatin regulation: from neural stem cell identity to brain tumour dependency." The seminar will take place in the...