Dr. Hiroshi Kimura
Institute of Quantitative Biosciences, University of Tokyo, Japan
Invited by Dr. Pierre-Antoine Defossez
“Dynamics of chromatin modification and transcription in vivo.”
The seminar is Zoom-only
On Wednesday, May 20that 11:00 am.
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09
ID de réunion : 861 1442 2072
Code secret: 492809
Relevant publications from the speaker:
Galindo G, Maejima D, DeRoo J, …, Kimura H*, Stasevich TJ*.
Sci Adv. 2026 Jan 2;12(1):eadx8352. doi: 10.1126/sciadv.adx8352. Epub 2026 Jan 2. PMID: 41481731
ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin.
Goto N, Suke K, Yonezawa N, Nishihara H, …, Kurumizaka H, Yamagata K, Kimura H.
J Cell Biol. 2024 Aug 5;223(8):e202310084. doi: 10.1083/jcb.202310084. Epub 2024 May 6. PMID: 38709169
Transcription bodies regulate gene expression by sequestering CDK9.
Ugolini M, Kerlin MA, Kuznetsova K, Oda H, Kimura H, Vastenhouw NL.
Nat Cell Biol. 2024 Apr;26(4):604-612. doi: 10.1038/s41556-024-01389-9. PMID: 38589534
Sato Y, Kimura H.
Methods Mol Biol. 2021;2329:237-247. doi: 10.1007/978-1-0716-1538-6_17.PMID: 34085227
Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input.
Handa T, Harada A, Maehara K, Sato S, Nakao M, Goto N, Kurumizaka H, Ohkawa Y, Kimura H.
Nat Protoc. 2020 Oct;15(10):3334-3360. doi: 10.1038/s41596-020-0375-8. Epub 2020 Aug 17.PMID: 32807906
Happy Birthday EDC !
On 8 October 2024, our unit celebrated it's 15th anniversary but also 15 years of scientific and technical advances.It was a great day, both scientifically and humanly. From left to right : Ariane, Jérémy, Charles, Emmanuelle, Jonathan, Camille (front), Angélique,...
EDC15: Fifteen Years of Epigenetics and Cell Fate
The Epigenetics and Cell Fate Center celebrates its fifteen years of existence on October 8, 2024. Come, and join us for this special day! This conference will look back on 15 years of scientific advances in the fields of epigenetics and cellular differentiation in...
2024 Young Scientists Day
It’s time to create our own network! The 27th of June young scientists from BFA (Biologie Fonctionelle Adaptative), IJM (Institut Jacques Monod) and us (EDC) will meet to share amazing science and create the foundations of future collaborations...
Call for new Research Group Leaders
The Epigenetics and Cell Fate Centre is seeking to recruit two talented junior and/or senior group leaders.Download the call (.pdf) Download the application form (.doc) The Epigenetics and Cell Fate Centre is a leading institute exploring cell identity and...
Congratulations Dr Carrillo
Congratulations to Léo who defended his thesis work on " Exploring the link between X chromosome inactivation and the development of human extraembryonic tissues " . © Rougeulle team À lire aussi
Review on the chromatin-based regulation of genome maintenance
A review from our research group is out for publication in DNA Repair as part of the special issue "Cutting-Edge Perspectives in Genome Maintenance". This review presents our current knowledge on the contribution of pre-existing and DNA damage-induced chromatin marks...
Elphège Nora seminar – June 19, 2024
Wednesday, June 19, 2024, at 11:00 am. Elphège Nora UCSF, San FranciscoInvited by Claire Rougeulle “Molecular mechanisms of chromosome folding and enhancer wiring” The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Buffon building, 15 rue...
Article: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
Our latest work carried out by Alfeghaly C. et al. elucidating the mechanism of dampening of X-linked gene expression during pre-implantation development. To discover the role of the long non-coding RNA XIST and its particular partner SPEN click on the link: Nature...
Summer School on Artificial Intelligence in Biology and Genetics
Souhila Medjkane is organizing the Summer School "How Artificial Intelligence is Revolutionizing Biology and Genetics" on July 9-11, 2024. Université Paris Cité, Grands Moulins campus © Université Paris Cité The workshop will take place in Fontainebleau on July...
4th year PhD fellowships to Giulia and Margherita
Congratulations to Giulia Giacomini and Margherita Mori for obtaining 4th year PhD fellowships from the Fondation pour la Recherche Médicale (FRM) and la Ligue contre le Cancer. Giulia Giacomini (left) and Margherita Mori (right) © Eliane Petit À lire...
Elisa Bergamin seminar – June 5, 2024
Wednesday, June 5, 2024, at 11:00 am. Elisa Bergamin IGBMC, StrasbourgInvited by Sophie Polo “Structural and functional studies of mammalian SWI/SNF in health and disease” The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Buffon...
Article: Altered X-chromosome inactivation predisposes to autoimmunity
Our latest work by Huret et al. linking X chromosome inactivation to autoimmunity is published in Science Advances This work is discussed in different journals: NewScientist: Autoimmune conditions linked to reactivated X chromosome genes National Geographic: Why women...
Theileria annulata and Cancer: a parasite strategy revealed!
Laetitia Aubry seminar – April 24, 2024
Wednesday, April 24, 2024, at 11:00 am. Laetitia Aubry Université d’Evry / I-StemInvited by Valérie Drouet “Harnessing pluripotent stem cells derivatives from patients with Wolfram syndrome to reveal pathological mechanisms and identify potential therapeutic chemical...
Moussa Benhamed seminar – April 17, 2024
Wednesday, April 17, 2024, at 11:00 am. Moussa Benhamed Institute of Plant Sciences, Paris SaclayInvited by Valérie Mezger “Exploring the chromatin-based regulation of enhancer-promoter contact and its impact on gene expression” The seminar will take place in the...
Professional afterwork – April 22, 2024
Do you know what else exists outside academia?Come to talk about it with our two guests on Monday, April 22, 2024, at 6.15 pm. Where? Epigenetics and Cell Fate Center (EDC)Université Paris Cité - 35 Rue Helene Brion 75013 Paris – Lamarck B building - Hall (Upper...
Manuel Muñoz seminar – March 6, 2024
Wednesday, March 6, 2024, at 11:00 am Manuel Muñoz University of Buenos Aires-CONICET, ArgentinaInvited by Sophie Polo “RNA polymerase II abundance is controlled by DNA repair” The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Buffon...
Jean-Christophe Andrau seminar – February 28, 2024
Wednesday, February 28, 2024, at 11:00 amJean-Christophe Andrau IGMM, MontpellierInvited by Pierre-Antoine Defossez “Secondary DNA structures contribute to promoter activity as nucleosome exclusion modules” The seminar will take place in the Institut Jacques Monod...
EMBO Workshop “Chromatin dynamics and nuclear organization in genome maintenance”
Sophie Polo is co-organizing the third edition of the EMBO Workshop "Chromatin dynamics and nuclear organization in genome maintenance". © https://meetings.embo.org/event/24-chromatin-dynamics The workshop will take place in Leiden, Netherlands, from June 17 to 20,...
New research article on the impact of histone oncomutations on genome maintenance
January 12th 2024: We have uncovered an altered DNA repair activity in H3.3 mutant pediatric high-grade glioma that fosters genome instability independently of previously described oncogenic pathways. Furthermore, we have identified a DNA repair enzyme that sustains...