Dr. Philipp Voigt
Babraham Institute, Cambridge, UK
“Decoding bivalency: Mechanisms of poising at developmental gene promoters.”
The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).
Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th.
On Wednesday, October 7th at 11:00 am.
Zoom link for remote attendees:
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09
Meeting ID: 861 1442 2072
Secret code: 492809
Relevant publications from the speaker
H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability.
Yuan W, Huang YC, LeBlanc C, Poulet A, De Luna Vitorino FN, Valsakumar D, Dean R, Garcia BA, van Wolfswinkel JC, Voigt P, Jacob Y. Nat Commun. 2025 Apr 14;16(1):3547. doi: 10.1038/s41467-025-58892-2.
Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains.
Bryan E, Valsakumar D, Idigo NJ, Warburton M, Webb KM, McLaughlin KA, Spanos C, Lenci S, Major V, Ambrosi C, Andrews S, Baubec T, Rappsilber J, Voigt P. Mol Cell. 2025 Feb 6;85(3):471-489.e12. doi: 10.1016/j.molcel.2024.12.002.
The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Wapenaar H, Clifford G, Rolls W, Pasquier M, Burdett H, Zhang Y, Deák G, Zou J, Spanos C, Taylor MRD, Mills J, Watson JA, Kumar D, Clark R, Das A, Valsakumar D, Bramham J, Voigt P, Sproul D, Wilson MD. EMBO Rep. 2024 Dec;25(12):5743-5779. doi: 10.1038/s44319-024-00306-3.
Nucleosomal asymmetry: a novel mechanism to regulate nucleosome function.
Valsakumar D, Voigt P. Biochem Soc Trans. 2024 Jun 26;52(3):1219-1232. doi: 10.1042/BST20230877
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