In this paper, we identify new players in chromatin repair through a novel approach for the proteomic profiling of DNA repair patches in human cells. Thus, we expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a mechanistic coordination between old and new histone dynamics.
For more details, see Plessier*, Chansard*, Petit* et al., Nat Commun 2026.
Working model showing the histone chaperones DNAJC9 and MCM2 that are recruited to sites of UV damage repair and jointly coordinate old and new histone H3-H4 dynamics during chromatin repair.
À lire aussi
Seminar Eugene Gladyshev –November 18, 2026
Dr. Eugene Gladyshev Molecular Genetics and Epigenetics Unit, Department of Mycology, Institut Pasteur "Homology-dependent initiation of gene silencing in N.crassa is mediated by ATRX/SAD-6." Abstract: Our group studies several genome-defense processes in the fungus...
Seminar Alex de Mendoza – October 21, 2026
Dr. Alex de Mendoza Center for Epigenetics, Queen Mary University of London, UK Invited by Dr. Pierre-Antoine Defossez "Tracing the Evolution of DNA Methylation Mechanisms across the Eukaryotes" The seminar will take place on Wednesday, October 21st at 11:00 am. Zoom...
Seminar Jan Padeken –October 14, 2026
Dr. Jan Padeken Institute of Molecular Biology, Mainz, Germany "UV-Damage-induced Epigenetic Memory in Organismal Resilience and Aging." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th....
Seminar Philipp Voigt –October 7, 2026
Dr. Philipp Voigt Babraham Institute, Cambridge, UK "Decoding bivalency: Mechanisms of poising at developmental gene promoters." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th. On...