In this paper, we identify new players in chromatin repair through a novel approach for the proteomic profiling of DNA repair patches in human cells. Thus, we expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a mechanistic coordination between old and new histone dynamics.
For more details, see Plessier*, Chansard*, Petit* et al., Nat Commun 2026.
Working model showing the histone chaperones DNAJC9 and MCM2 that are recruited to sites of UV damage repair and jointly coordinate old and new histone H3-H4 dynamics during chromatin repair.
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Call for new Research Group Leader
The CNRS is launching a call for applications for a Junior Professor Chair (Chaire de Professeur Junior, CPJ) entitled “Epigenetics of Cellular Fate (EpiDeC)”, hosted at our Centre. All details in this document.
Sophie Polo elected EMBO member
Honored to be part of this prestigious scientific community. Sophie Polo in her laboratory © Romain Redler / Art in research for the Fondation Bettencourt Schueller À lire aussi
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In this paper, we show that SETDB1 regulates the TGFβ-induced secretome and identify EMILIN1, an extracellular matrix protein, as a novel player in this process. EMILIN1 is overexpressed in muscle biopsies from DMD patients and influences both myogenic differentiation...
Seminar Benoît MOINDROT –July 8, 2026
Dr. Benoît MOINDROT The Institute for Integrative Biology of the Cell (I2BC), University Paris-Saclay Invited by Dr. Dounia DJEGHLOUL "One Genome, Two Voices: Decoding allelic chromatin-regulatory layers, and their perturbations, at imprinted domains." The seminar...