Dr. Laure Bally-Cuif
Institut Pasteur and CNRS, Paris, France
Invited by Dr. Valérie Mezger
“Making sense of adult Neural Stem Cell heterogeneities“
The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).
Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th.
On Wednesday, January 28that 11:00 am.
Neural stem cell (NSC) populations ensure the production of neurons and astroglial cells in the vertebrate adult brain. NSC activity persists at long-term in zebrafish, but exhausts rapidly in mouse from the young adult stage. Using long-term genetic clonal tracing and intravital imaging in the zebrafish adult pallium (dorsal telencephalon), we revealed that two distinct NSC sub-populations cooperate to ensure population maintenance and neurogenesis. These sub-populations are endowed with self-renewal vs neurogenesis capacity and are organized in a functional hierarchy. Using sc-omics, we and others observed that these sub-population are themselves molecularly heterogeneous. The biological significance and regulation of these heterogeneities are unknown, as well as how they remain balanced in time and space over a lifetime. I will show our latest results on these questions, showing how we are taking in situ approaches and readouts of Notch3 signaling to decipher individual NSC trajectories and their coordination within the transcriptomic and physical spaces.
Congratulations to Dr. Silvia Comunian!
On September 25, 2026, Silvia successfully defended her thesis: “Epigenetic control of nuclear mechanics and migration via H3K9 methylation at Lamina-Associated Domains in lung cancer cells”Silvia Comunian and the jury members: Yegor Vassetzky, Nicolas Borghi,...
Welcome to Sara
Sara is joining the team for a master’s internship. As a student in the Interdisciplinary Master’s in Life Sciences program at the Ecole Normale Superieure, Sara will contribute to a research project aimed at identifying vulnerabilities in DNA repair in high-grade...
Seminar Cristiano SIMONE –September 30, 2026
Dr. Cristiano SIMONE University of Bari Aldo Moro, Bari, ItalyInvited by Dr. Souhila MEDJKANE "Unraveling SMYD3 functions along the Cancer Hallmark trail." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène...
Seminar Charles Williams –September 23, 2026
Dr. Charles Williams MRC Centre for Regenerative Medicine, The University of Edinburgh Invited by Dr. Dounia DJEGHLOUL "Mitotic bookmarking and chromatin regulation: from neural stem cell identity to brain tumour dependency." The seminar will take place in the...
Seminar Laurent CHATRE –September 9, 2026
Dr. Laurent CHATRE ISTCT, UMR6030 CNRS, Université de Caen Normandie Invited by Dr. Dounia DJEGHLOUL "Reframing Epigenetics: Metabolism, Mitochondria, and Redox as Core Regulatory Layers." The seminar will take place in the Institut Jacques Monod seminar room...
Call for new Research Group Leader
The CNRS is launching a call for applications for a Junior Professor Chair (Chaire de Professeur Junior, CPJ) entitled “Epigenetics of Cellular Fate (EpiDeC)”, hosted at our Centre. All details in this document.
Sophie Polo elected EMBO member
Honored to be part of this prestigious scientific community. Sophie Polo in her laboratory © Romain Redler / Art in research for the Fondation Bettencourt Schueller À lire aussi
New research article on the role of SETDB1 in regulating inflammation and fibrosis in Duchenne muscular dystrophy
In this paper, we show that SETDB1 regulates the TGFβ-induced secretome and identify EMILIN1, an extracellular matrix protein, as a novel player in this process. EMILIN1 is overexpressed in muscle biopsies from DMD patients and influences both myogenic differentiation...
Seminar Benoît MOINDROT –July 8, 2026
Dr. Benoît MOINDROT The Institute for Integrative Biology of the Cell (I2BC), University Paris-Saclay Invited by Dr. Dounia DJEGHLOUL "One Genome, Two Voices: Decoding allelic chromatin-regulatory layers, and their perturbations, at imprinted domains." The seminar...
Seminar Adam SATERIALE –June 17, 2026
Dr. Adam Sateriale The Francis Crick Institute, London, UK Invited by Jonathan Weitzman and Marisol Giacomini "Intestinal parasites and metabolic mysteries." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Bâtiment Buffon, 15...
Seminar Michael Rera –June 3, 2026
Dr. Michael Rera Department of Functional and Adaptive Biology, Université Paris Cité, France Invited by Dr. Valerie Mezger "Studying ageing as a two-phase process." The hallmarks of aging framework, introduced over a decade ago and cited nearly 20,000 times, became...
Seminar Anne-Sophie Lebre– May 27, 2026
Pr. Anne-Sophie Lebre CHU de Reims - Hôpital Robert Debré, France Invited by Pr. Bertrand Cosson "Brain (epi)genome study in CNS rare disorders" The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Bâtiment Buffon, 15 rue Hélène Brion,...
Seminar Hiroshi Kimura– May 20, 2026
Dr. Hiroshi Kimura Institute of Quantitative Biosciences, University of Tokyo, Japan Invited by Dr. Pierre-Antoine Defossez "Dynamics of chromatin modification and transcription in vivo." The seminar is Zoom-only On Wednesday, May 20that 11:00 am....
Bing Zhu Seminar – May 6, 2026
Dr. Bing Zhu Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Invited by Dr. Pierre-Antoine Defossez "Epigenetics: remember the past & prepare for the future." The seminar is Zoom-only On Wednesday, May 6that 11:00 am....
Harm H. Kampinga Seminar – April 15, 2026
Dr. Harm H. Kampinga Dept. Biomedical Sciences, UMCG/RuG, Groningen, The Netherlands Invited by Dr. Valérie Mezger "Collapse of protein homeostasis as driver of age-related protein aggregation diseases" The seminar will take place in the Institut Jacques Monod seminar...
Frédéric Frottin Seminar – April 8, 2026
Dr. Frédéric Frottin I2BC, Gif-sur-Yvette, France Invited by Dr. Valérie Mezger "The nucleolus as a hot spot in nuclear proteostasis - Molecular basis of the accumulation of misfolded proteins into the nucleolus" The seminar will take place in the...
Pint of Science 2026: Our unit takes Science to the public!
The Pint of Science festival returns from May 18 to 20, 2026. This year, members of our unit are once again deeply involved in bringing cutting-edge research out of the labs and into the relaxed atmosphere of Parisian bars. Featured Event: "DNA Damage, Cancer and...
Congratulations to the Defossez group for their review published in Médecine/Sciences
Congratulations to Matthieu, Raady and Pierre-antoine for their review "Demethylating DNA against cancer : towards new epigenetic therapeutic strategies without DNA damage" published in Médecine/Sciences in february 2026! Read here
New research article on histone chaperones with central functions in chromatin repair
In this paper, we identify new players in chromatin repair through a novel approach for the proteomic profiling of DNA repair patches in human cells. Thus, we expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a...
Dimitris Xirodimas Seminar – March 11, 2026
Dr. Dimitris Xirodimas CRBM-CNRS, Montpellier, France Invited by Dr. Valérie Mezger "Guardians of Proteostasis: Ubiquitin and Ubiquitin-like pathways in Protein Misfolding and Aggregation" The seminar will take place in the Institut Jacques Monod seminar room...