Dr. Dimitris Xirodimas

CRBM-CNRS, Montpellier, France

Invited by Dr. Valérie Mezger

“Guardians of Proteostasis: Ubiquitin and Ubiquitin-like pathways in Protein Misfolding and Aggregation

The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).

Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th.

On Wednesday, March 11th at 11:00 am.

Relevant publications from the speaker:

A nuclear protein quality control system for elimination of nucleolus-related inclusions.

Brunello L, Polanowska J, Le Tareau L, Maghames C, Georget V, Guette C, Chaoui K, Balor S, O’Donohue MF, Bousquet MP, Gleizes PE, Xirodimas DP. EMBO J. doi: 10.1038/s44318-024-00333-9 (2025).

Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly.

Kassouf T, Shrivastava R, Meszka I, Bailly A, Polanowska J, Trauchessec H, Mandrioli J, Carra S, Xirodimas DP. Sci Adv. 9(13):eabq7585. doi: 10.1126/sciadv.abq7585 (2023).

Proteome-wide identification of NEDD8 sites reveals distinct proteomes for canonical and atypical NEDDylation.

Lobato GS, Heidelberger BJ, Maghames C, Bailly A, Brunello L, Rodriguez MS, Beli P and Xirodimas DP. Cell Reports, 34(3):108635. doi: 10.1016/j.celrep.2020.108635. (2021).

The balance between mono and NEDD8-chains controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity.

Bailly AP, Perrin A, Marina Serrano-Macia, Maghames C, Leidecker O, Trauchessec H, ML Martinez-Chantar, Gartner A and Xirodimas DP. Cell Reports 29, 212–224. (2019).

Welcome to Léa, new engineer in the team!

Welcome to Léa, new engineer in the team!

Léa joins the lab as a research assistant. She holds a Master's degree in Molecular and Cellular Biology from Sorbonne University. She will contribute to investigate DNA methylation maintenance mechanisms in response to UV damage in mammalian cells. Léa Girard À lire...

Well done, Dr Mori!

Well done, Dr Mori!

Margherita successfully defended her PhD on DNA methylation maintenance in response to UV damage. Brava! Margherita and her thesis jury. From left to right: Sophie Polo, Sandra Duharcourt (on screen), Déborah Bourc'his, Margherita Mori, Nataliya Petryk, Jean Molinier,...

Congratulations Dr Giacomini!

Congratulations Dr Giacomini!

Giulia defended her PhD on the impact of high grade glioma-associated histone H3 mutations on genome integrity. Congratulations to her on a fantastic thesis defense! Giulia Giacomini and her thesis jury. From left to right: Beatrice Rondinelli, Keith Caldecott,...

Welcome to Annabelle, new post-doc in the team!

Welcome to Annabelle, new post-doc in the team!

Annabelle joins the lab as a post-doctoral fellow. She completed her PhD at the University of Oxford under the supervision of Prof. Monika Gullerova. Her doctoral work focused on the role of small non-coding Y RNAs and the RNA-binding protein, YBX1, in intracellular...

Welcome to Orlane

Welcome to Orlane

Today, we welcome a new member to the team: Orlane. She's a student from the first year of the Brevet de Technicien Supérieur Biotechnologies en Recherche et Production (Two-year technical degree - Biotechnologies in Research and Production).Orlane will be working...

Welcome to Delphine, new post-doc in the team!

Welcome to Delphine, new post-doc in the team!

Delphine joins the lab as a post-doctoral fellow. She completed her PhD at the Centre de Recherche en Cancérologie de Lyon (CRCL) under the supervision of Virginie Petrilli. Her doctoral work focused on the pro-inflammatory protein NLRP3, for which she highlighted a...

Welcome to Julia

Welcome to Julia

Julia Roche Dupuy joined the lab for her second year Master's internship. Julia Roche Dupuy Second year Master's student À lire aussi

Welcome Caroline to our team!

Welcome Caroline to our team!

We're excited to have Caroline joining Dr. Ait-si-Ali's team! She comes to us as an M2 student from the GENE2 master's program at Université Paris-Saclay. Working with Dr. Guillaume Velasco, Caroline will study the regulation of nuclear stiffness by H3K9...

Welcome Minh to Slimane Ait-si-ali’s team!

Welcome Minh to Slimane Ait-si-ali’s team!

We are delighted to welcome Mynh, an M2 student from the GENE2 master's program at Université Paris-Saclay, to Dr. Ait-si-Ali's team. Mynh will be investigating the role of SETDB1 in Duchenne muscular dystrophy phenotype development.   

Welcome to Steve

Welcome to Steve

Today, we welcome a new member to the team: Steve, a M2 student from the Magistère Européen de Génétique and an EUR GENE fellow.Steve will be working on the interactions of recently identified new parasite protein.Read more