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New research article on how chromatin marking governs DNA damage segregation in mitosis
In this paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis with potential consequences on daughter cell fate. Thus, we reveal that chromatin alterations impinge on genome stability not only by...
Welcome to Julia
Julia Roche Dupuy joined the lab for her second year Master's internship. Julia Roche Dupuy Second year Master's student À lire aussi
Welcome Caroline to our team!
We're excited to have Caroline joining Dr. Ait-si-Ali's team! She comes to us as an M2 student from the GENE2 master's program at Université Paris-Saclay. Working with Dr. Guillaume Velasco, Caroline will study the regulation of nuclear stiffness by H3K9...
Welcome Minh to Slimane Ait-si-ali’s team!
We are delighted to welcome Mynh, an M2 student from the GENE2 master's program at Université Paris-Saclay, to Dr. Ait-si-Ali's team. Mynh will be investigating the role of SETDB1 in Duchenne muscular dystrophy phenotype development.
Welcome to Steve
Today, we welcome a new member to the team: Steve, a M2 student from the Magistère Européen de Génétique and an EUR GENE fellow.Steve will be working on the interactions of recently identified new parasite protein.Read more
New review: X chromosome regulation and female functional specificities: Are two Xs better than one?
What if the presence of two X chromosomes confers functional specificities on female cells and contributes to the different susceptibilites of men and women to certain diseases? One of the X chromosomes is randomly silenced in each female cell from the embryonic...
New review: Genetic diseases of epigenetic machinery
The development of sequencing technologies and their increased accessibility in clinical services and genetic laboratories have considerably accelerated the identification of genetic variants associated with rare diseases. Among these, Mendelian disorders of the...
Congratulations to Guillaume!
Congratulations to Dr Guillaume Velasco on obtaining his Habilitation à Diriger des Recherches (HDR) this Wednesday, December 18th. A well-deserved accomplishment!Jury members: Giséle Bonne, Jean-Charles Cadoret, Fabienne Malagnac and Guillermo OrsiCongratulations,...
Congratulations to Dr. Carole Chaput
Congratulations to Dr. Carole Chaput who defended her thesis this Friday, December 6, 2024 on « Therapeutic functionalization of a rare neurodevelopmental and monogenic disease model based on the contribution of the heat shock factor 2 stress pathway »À lire aussi
Congratulations to Dr. Kevin Daupin
Congratulations to Dr. Kevin Daupin who defended his thesis this Wednesday, December 4, 2024 on « Integrity of Neuroepithelium & the Neural Niche in Rubinstein-Taybi Syndrome Derived Neural Models : A perspective on the implication of HSF2 pathways dysregulations...
Welcome to Megan
Today, we welcome a new member to the team: Megan, a M1 student from the EPHE where she's doing the Integrative Master for Global Health and Ecology, Integrative Physiopathology course.Megan will be working with Souhila on lysine methylation signalling by SMYD2.Read...
New review: Unleashing XIST from X-chromosome inactivation
The discovery that long noncoding RNAs (lncRNAs) are the most abundant gene class in the human genome has sparked significant research, particularly on Xist, a key RNA involved in X-chromosome inactivation. Recent studies have expanded our understanding of Xist's...