Dr. Hiroshi Kimura
Institute of Quantitative Biosciences, University of Tokyo, Japan
Invited by Dr. Pierre-Antoine Defossez
“Dynamics of chromatin modification and transcription in vivo.”
The seminar is Zoom-only
On Wednesday, May 20that 11:00 am.
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09
ID de réunion : 861 1442 2072
Code secret: 492809
Relevant publications from the speaker:
Galindo G, Maejima D, DeRoo J, …, Kimura H*, Stasevich TJ*.
Sci Adv. 2026 Jan 2;12(1):eadx8352. doi: 10.1126/sciadv.adx8352. Epub 2026 Jan 2. PMID: 41481731
ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin.
Goto N, Suke K, Yonezawa N, Nishihara H, …, Kurumizaka H, Yamagata K, Kimura H.
J Cell Biol. 2024 Aug 5;223(8):e202310084. doi: 10.1083/jcb.202310084. Epub 2024 May 6. PMID: 38709169
Transcription bodies regulate gene expression by sequestering CDK9.
Ugolini M, Kerlin MA, Kuznetsova K, Oda H, Kimura H, Vastenhouw NL.
Nat Cell Biol. 2024 Apr;26(4):604-612. doi: 10.1038/s41556-024-01389-9. PMID: 38589534
Sato Y, Kimura H.
Methods Mol Biol. 2021;2329:237-247. doi: 10.1007/978-1-0716-1538-6_17.PMID: 34085227
Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input.
Handa T, Harada A, Maehara K, Sato S, Nakao M, Goto N, Kurumizaka H, Ohkawa Y, Kimura H.
Nat Protoc. 2020 Oct;15(10):3334-3360. doi: 10.1038/s41596-020-0375-8. Epub 2020 Aug 17.PMID: 32807906
Congratulations to Souhila, promoted full Professor !
We are delighted to announce the success of Souhila MEDJKANE, who has been promoted to full Professor!On September 1, 2025, Souhila was officially promoted to Professor. This is a major milestone in her career, and a source of great pride for our team and the teaching...
Congratulations to Delphine and Julia for their research funding
Congratulations to Delphine Burlet on getting a postdoctoral grant from the Fondation de France and to Julia Roche Dupuy who obtained a fellowship from the HOB doctoral school to finance her PhD thesis. Delphine Burlet, Julia Roche Dupuy À lire aussi
Welcome to Annabelle, new post-doc in the team!
Annabelle joins the lab as a post-doctoral fellow. She completed her PhD at the University of Oxford under the supervision of Prof. Monika Gullerova. Her doctoral work focused on the role of small non-coding Y RNAs and the RNA-binding protein, YBX1, in intracellular...
Welcome to Orlane
Today, we welcome a new member to the team: Orlane. She's a student from the first year of the Brevet de Technicien Supérieur Biotechnologies en Recherche et Production (Two-year technical degree - Biotechnologies in Research and Production).Orlane will be working...
4th year PhD fellowships for Anaëlle
Congratulations to Anaëlle Azogui for obtaining a 4th year PhD fellowships from the "Fondation pour la recherche sur le cancer" (Fondation ARC). Read more
Congratulations to the Defossez team for their article published in Nature Communication
Congratulations to the Defossez team for their article “DNA methylation protects cancer cells against senescence” by Chen, Yamaguchi, et al., which has been accepted in Nature Communication. Read it here: doi:doi: https://doi.org/10.1101/2024.08.23.609297...
Welcome to Delphine, new post-doc in the team!
Delphine joins the lab as a post-doctoral fellow. She completed her PhD at the Centre de Recherche en Cancérologie de Lyon (CRCL) under the supervision of Virginie Petrilli. Her doctoral work focused on the pro-inflammatory protein NLRP3, for which she highlighted a...
New research article on how chromatin marking governs DNA damage segregation in mitosis
In this paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis with potential consequences on daughter cell fate. Thus, we reveal that chromatin alterations impinge on genome stability not only by...
Welcome to Julia
Julia Roche Dupuy joined the lab for her second year Master's internship. Julia Roche Dupuy Second year Master's student À lire aussi
Welcome Caroline to our team!
We're excited to have Caroline joining Dr. Ait-si-Ali's team! She comes to us as an M2 student from the GENE2 master's program at Université Paris-Saclay. Working with Dr. Guillaume Velasco, Caroline will study the regulation of nuclear stiffness by H3K9...
Welcome Minh to Slimane Ait-si-ali’s team!
We are delighted to welcome Mynh, an M2 student from the GENE2 master's program at Université Paris-Saclay, to Dr. Ait-si-Ali's team. Mynh will be investigating the role of SETDB1 in Duchenne muscular dystrophy phenotype development.
Welcome to Steve
Today, we welcome a new member to the team: Steve, a M2 student from the Magistère Européen de Génétique and an EUR GENE fellow.Steve will be working on the interactions of recently identified new parasite protein.Read more
New review: X chromosome regulation and female functional specificities: Are two Xs better than one?
What if the presence of two X chromosomes confers functional specificities on female cells and contributes to the different susceptibilites of men and women to certain diseases? One of the X chromosomes is randomly silenced in each female cell from the embryonic...
New review: Genetic diseases of epigenetic machinery
The development of sequencing technologies and their increased accessibility in clinical services and genetic laboratories have considerably accelerated the identification of genetic variants associated with rare diseases. Among these, Mendelian disorders of the...
Congratulations to Guillaume!
Congratulations to Dr Guillaume Velasco on obtaining his Habilitation à Diriger des Recherches (HDR) this Wednesday, December 18th. A well-deserved accomplishment!Jury members: Giséle Bonne, Jean-Charles Cadoret, Fabienne Malagnac and Guillermo OrsiCongratulations,...
Congratulations to Dr. Carole Chaput
Congratulations to Dr. Carole Chaput who defended her thesis this Friday, December 6, 2024 on « Therapeutic functionalization of a rare neurodevelopmental and monogenic disease model based on the contribution of the heat shock factor 2 stress pathway »À lire aussi
Congratulations to Dr. Kevin Daupin
Congratulations to Dr. Kevin Daupin who defended his thesis this Wednesday, December 4, 2024 on « Integrity of Neuroepithelium & the Neural Niche in Rubinstein-Taybi Syndrome Derived Neural Models : A perspective on the implication of HSF2 pathways dysregulations...
Welcome to Megan
Today, we welcome a new member to the team: Megan, a M1 student from the EPHE where she's doing the Integrative Master for Global Health and Ecology, Integrative Physiopathology course.Megan will be working with Souhila on lysine methylation signalling by SMYD2.Read...
New review: Unleashing XIST from X-chromosome inactivation
The discovery that long noncoding RNAs (lncRNAs) are the most abundant gene class in the human genome has sparked significant research, particularly on Xist, a key RNA involved in X-chromosome inactivation. Recent studies have expanded our understanding of Xist's...
Congratulations to Emmanuelle !
Last week, Emmanuelle Ceddaha, one of our PhD student, defended her pharmacy thesis. It was a great presentation which not only earned her the congratulations of the jury, but also the distinction of ‘very good’ (and the unofficial distinction of ‘excellent’) for her...