Dr. Alex de Mendoza
Center for Epigenetics, Queen Mary University of London, UK
Invited by Dr. Pierre-Antoine Defossez
“Tracing the Evolution of DNA Methylation Mechanisms across the Eukaryotes”
The seminar will take place on Wednesday, October 21st at 11:00 am.
Zoom link for remote attendees:
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09
Meeting ID: 861 1442 2072
Secret code: 492809
Relevant publications from the speaker
Publications de l’intervenant :
Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian.
Xu L, Heery R, Baranasic D, Žunar B, Segura Campaña A, Ovchinnikov V, Lenhard B, de Mendoza A. Nat Ecol Evol. 2026 Jul;10(7):1370-1383. PMID: 42231006;
doi: 10.1038/s41559-026-03090-6.
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes.
Romero Charria P, Navarrete C, Ovchinnikov V, Xu L, Sarre LA, Shabardina V, Ksiezopolska E, Casacuberta E, Lara-Astiaso D, Sebé-Pedrós A, de Mendoza A.
Nat Genet. 2025 Dec;57(12):3126-3136. PMID: 41254163; doi: 10.1038/s41588-025-02409-6.
DNA methylation enables recurrent endogenization of giant viruses in an animal relative.
Sarre LA, Kim IV, Ovchinnikov V, Olivetta M, Suga H, Dudin O, Sebé-Pedrós A, de Mendoza A. Sci Adv. 2024 Jul 12;10(28):eado6406.PMID: 38996012;
doi: 10.1126/sciadv.ado6406.
New research article on histone chaperones with central functions in chromatin repair
In this paper, we identify new players in chromatin repair through a novel approach for the proteomic profiling of DNA repair patches in human cells. Thus, we expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a...
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