Dr. Laure Bally-Cuif

Institut Pasteur and CNRS, Paris, France

Invited by Dr. Valérie Mezger

“Making sense of adult Neural Stem Cell heterogeneities“

The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).

Bâtiment Buffon, 15 rue Hélène Brion, Paris 13^th.

On Wednesday, January 28^that 11:00 am.

Neural stem cell (NSC) populations ensure the production of neurons and astroglial cells in the vertebrate adult brain. NSC activity persists at long-term in zebrafish, but exhausts rapidly in mouse from the young adult stage. Using long-term genetic clonal tracing and intravital imaging in the zebrafish adult pallium (dorsal telencephalon), we revealed that two distinct NSC sub-populations cooperate to ensure population maintenance and neurogenesis. These sub-populations are endowed with self-renewal vs neurogenesis capacity and are organized in a functional hierarchy. Using sc-omics, we and others observed that these sub-population are themselves molecularly heterogeneous. The biological significance and regulation of these heterogeneities are unknown, as well as how they remain balanced in time and space over a lifetime. I will show our latest results on these questions, showing how we are taking in situ approaches and readouts of Notch3 signaling to decipher individual NSC trajectories and their coordination within the transcriptomic and physical spaces.