Dr. Dimitris Xirodimas

CRBM-CNRS, Montpellier, France

Invited by Dr. Valérie Mezger

“Guardians of Proteostasis: Ubiquitin and Ubiquitin-like pathways in Protein Misfolding and Aggregation“

The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).

Bâtiment Buffon, 15 rue Hélène Brion, Paris 13^th.

On Wednesday, March 11^th at 11:00 am.

Relevant publications from the speaker:

A nuclear protein quality control system for elimination of nucleolus-related inclusions.

Brunello L, Polanowska J, Le Tareau L, Maghames C, Georget V, Guette C, Chaoui K, Balor S, O’Donohue MF, Bousquet MP, Gleizes PE, Xirodimas DP. EMBO J. doi: 10.1038/s44318-024-00333-9 (2025).

Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly.

Kassouf T, Shrivastava R, Meszka I, Bailly A, Polanowska J, Trauchessec H, Mandrioli J, Carra S, Xirodimas DP. Sci Adv. 9(13):eabq7585. doi: 10.1126/sciadv.abq7585 (2023).

Proteome-wide identification of NEDD8 sites reveals distinct proteomes for canonical and atypical NEDDylation.

Lobato GS, Heidelberger BJ, Maghames C, Bailly A, Brunello L, Rodriguez MS, Beli P and Xirodimas DP. Cell Reports, 34(3):108635. doi: 10.1016/j.celrep.2020.108635. (2021).

The balance between mono and NEDD8-chains controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity.

Bailly AP, Perrin A, Marina Serrano-Macia, Maghames C, Leidecker O, Trauchessec H, ML Martinez-Chantar, Gartner A and Xirodimas DP. Cell Reports 29, 212–224. (2019).