Aurélie De Thonel and the V Mezger lab released a paper in Nature Communications elucidating the relationship between CBP and HSF2 in a neurodevelopmental disorder, CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.
In the Rubinstein-Taybi syndrome (RSTS), patients carry dominant mutations in the histone/lysine acetyl transferases CBP or EP300 and suffer from neurodevelopmental disorder. The precise cellular dysfunctions causing the neurodevelopmental disorder remain however elusive as this enzyme have many targets beyond histone proteins. In this study, we show the contribution of a stress-responsive pathway in keeping the neural cell integrity as an early step toward the neural symptom of the disease. The heat-shock factor 2 (HSF2) is a fine tuner of brain cortical development and major player in prenatal stress responses in the neocortex. This study shows that CBP/EP300 acetylates HSF2, leading to the stabilization of the HSF2 protein. Consequently, RSTS patient cells showed decreased levels of HSF2 and their stress response was largely attenuated. Moreover, using 2D and 3D organoid models of cerebral development, the same CBP/EP300-HSF2 interactions were found as well as similar alterations of the stress response. Associated to this perturbed stress response, a decrease in a crucial neural cell adhesion protein, N-cadherin was observed and it could be rescued by stabilizing HSF2. Altogether the study highlights a crucial role of the HSF pathway in keeping neural cell integrity, a pathway particularly sensitive to stress and epigenetic alterations, two confounders of neurodevelopmental disorders.
Helping the “Palais de la Découverte” for their future exhibition
Katia, research engineer and CRISPR/Cas9 expert, welcomed a team from the "Palais de la Découverte" to help them prepare a future exhibition about genetics in the museum. Discover their visit through this short video (in French): Read more
Maria Rostovskaya seminar
Wednesday, April 26th, 2023, at 11:00 am Maria Rostovskaya Babraham Institute, Cambridge, UKInvited by Claire Rougeulle “Molecular timetables of differentiation: making the right shape at the right time” The seminar will take place in the Institut Jacques Monod...
Pierre-Antoine Defossez is nominated to the Editorial Board of “Epigenetics and Chromatin”
April 2023: Pierre-Antoine Defossez is nominated to the Editorial Board of “Epigenetics and Chromatin”. Congratulations! More about the journal's editorial board here:https://epigeneticsandchromatin.biomedcentral.com/about/editorial-board Epigenetics & Chromatin...
Guillaume Lamour seminar
Wednesday, April 19th, 2023, at 11:00 am Guillaume Lamour Evry University, FranceInvited by Slimane Ait-Si-Ali “Nanomechanics of stiff and soft biomaterials by atomic force microscopy” The seminar will take place in the Institut Jacques Monod seminar room (RB-18B)....