Welcome Caroline to our team!
We’re excited to have Caroline joining Dr. Ait-si-Ali’s team! She comes to us as an M2 student from the GENE2 master’s program at Université Paris-Saclay. Working with Dr. Guillaume Velasco, Caroline will study the regulation of nuclear stiffness by H3K9 methyltransferases.
Welcome Minh to Slimane Ait-si-ali’s team!
We are delighted to welcome Mynh, an M2 student from the GENE2 master's program at Université Paris-Saclay, to Dr. Ait-si-Ali's team. Mynh will be investigating the role of SETDB1 in Duchenne muscular dystrophy phenotype development.
Welcome to Steve
Today, we welcome a new member to the team: Steve, a M2 student from the Magistère Européen de Génétique and an EUR GENE fellow.Steve will be working on the interactions of recently identified new parasite protein.Read more
New review: X chromosome regulation and female functional specificities: Are two Xs better than one?
What if the presence of two X chromosomes confers functional specificities on female cells and contributes to the different susceptibilites of men and women to certain diseases? One of the X chromosomes is randomly silenced in each female cell from the embryonic...
New review: Genetic diseases of epigenetic machinery
The development of sequencing technologies and their increased accessibility in clinical services and genetic laboratories have considerably accelerated the identification of genetic variants associated with rare diseases. Among these, Mendelian disorders of the...
Congratulations to Guillaume!
Congratulations to Dr Guillaume Velasco on obtaining his Habilitation à Diriger des Recherches (HDR) this Wednesday, December 18th. A well-deserved accomplishment!Jury members: Giséle Bonne, Jean-Charles Cadoret, Fabienne Malagnac and Guillermo OrsiCongratulations,...
Congratulations to Dr. Carole Chaput
Congratulations to Dr. Carole Chaput who defended her thesis this Friday, December 6, 2024 on « Therapeutic functionalization of a rare neurodevelopmental and monogenic disease model based on the contribution of the heat shock factor 2 stress pathway »À lire aussi
Congratulations to Dr. Kevin Daupin
Congratulations to Dr. Kevin Daupin who defended his thesis this Wednesday, December 4, 2024 on « Integrity of Neuroepithelium & the Neural Niche in Rubinstein-Taybi Syndrome Derived Neural Models : A perspective on the implication of HSF2 pathways dysregulations...
Welcome to Megan
Today, we welcome a new member to the team: Megan, a M1 student from the EPHE where she's doing the Integrative Master for Global Health and Ecology, Integrative Physiopathology course.Megan will be working with Souhila on lysine methylation signalling by SMYD2.Read...
New review: Unleashing XIST from X-chromosome inactivation
The discovery that long noncoding RNAs (lncRNAs) are the most abundant gene class in the human genome has sparked significant research, particularly on Xist, a key RNA involved in X-chromosome inactivation. Recent studies have expanded our understanding of Xist's...
Congratulations to Emmanuelle !
Last week, Emmanuelle Ceddaha, one of our PhD student, defended her pharmacy thesis. It was a great presentation which not only earned her the congratulations of the jury, but also the distinction of ‘very good’ (and the unofficial distinction of ‘excellent’) for her...
Postdoctoral position in epigenetics and cancer
Applications are invited for a 3-year postdoctoral position in the laboratory of Dr. Sophie Polo. The position is available from January 2025 (open until filled). The proposed postdoctoral work aims at targeting the DNA repair defect that we identified in histone H3...
Happy Birthday EDC !
On 8 October 2024, our unit celebrated it's 15th anniversary but also 15 years of scientific and technical advances.It was a great day, both scientifically and humanly. From left to right : Ariane, Jérémy, Charles, Emmanuelle, Jonathan, Camille (front), Angélique,...
EDC15: Fifteen Years of Epigenetics and Cell Fate
The Epigenetics and Cell Fate Center celebrates its fifteen years of existence on October 8, 2024. Come, and join us for this special day! This conference will look back on 15 years of scientific advances in the fields of epigenetics and cellular differentiation in...
2024 Young Scientists Day
It’s time to create our own network! The 27th of June young scientists from BFA (Biologie Fonctionelle Adaptative), IJM (Institut Jacques Monod) and us (EDC) will meet to share amazing science and create the foundations of future collaborations...
Call for new Research Group Leaders
The Epigenetics and Cell Fate Centre is seeking to recruit two talented junior and/or senior group leaders.Download the call (.pdf) Download the application form (.doc) The Epigenetics and Cell Fate Centre is a leading institute exploring cell identity and...
Congratulations Dr Carrillo
Congratulations to Léo who defended his thesis work on " Exploring the link between X chromosome inactivation and the development of human extraembryonic tissues " . © Rougeulle team À lire aussi
Review on the chromatin-based regulation of genome maintenance
A review from our research group is out for publication in DNA Repair as part of the special issue "Cutting-Edge Perspectives in Genome Maintenance". This review presents our current knowledge on the contribution of pre-existing and DNA damage-induced chromatin marks...
Elphège Nora seminar – June 19, 2024
Wednesday, June 19, 2024, at 11:00 am. Elphège Nora UCSF, San FranciscoInvited by Claire Rougeulle “Molecular mechanisms of chromosome folding and enhancer wiring” The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Buffon building, 15 rue...
Article: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
Our latest work carried out by Alfeghaly C. et al. elucidating the mechanism of dampening of X-linked gene expression during pre-implantation development. To discover the role of the long non-coding RNA XIST and its particular partner SPEN click on the link: Nature...
Summer School on Artificial Intelligence in Biology and Genetics
Souhila Medjkane is organizing the Summer School "How Artificial Intelligence is Revolutionizing Biology and Genetics" on July 9-11, 2024. Université Paris Cité, Grands Moulins campus © Université Paris Cité The workshop will take place in Fontainebleau on July...