Polo group

Welcome to Léa, new engineer in the team!

Oct 1, 2025 | Polo group

Léa joins the lab as a research assistant. She holds a Master’s degree in Molecular and Cellular Biology from Sorbonne University. She will contribute to investigate DNA methylation maintenance mechanisms in response to UV damage in mammalian cells. Léa Girard À...

Well done, Dr Mori!

Sep 30, 2025 | Polo group

Margherita successfully defended her PhD on DNA methylation maintenance in response to UV damage. Brava! Margherita and her thesis jury. From left to right: Sophie Polo, Sandra Duharcourt (on screen), Déborah Bourc’his, Margherita Mori, Nataliya Petryk, Jean...

Congratulations Dr Giacomini!

Sep 23, 2025 | Polo group

Giulia defended her PhD on the impact of high grade glioma-associated histone H3 mutations on genome integrity. Congratulations to her on a fantastic thesis defense! Giulia Giacomini and her thesis jury. From left to right: Beatrice Rondinelli, Keith Caldecott,...

Congratulations to Delphine and Julia for their research funding

Jul 7, 2025 | Polo group

Congratulations to Delphine Burlet on getting a postdoctoral grant from the Fondation de France and to Julia Roche Dupuy who obtained a fellowship from the HOB doctoral school to finance her PhD thesis. Delphine Burlet, Julia Roche Dupuy À lire aussi Congratulations...

Welcome to Annabelle, new post-doc in the team!

Jul 1, 2025 | Polo group

Annabelle joins the lab as a post-doctoral fellow. She completed her PhD at the University of Oxford under the supervision of Prof. Monika Gullerova. Her doctoral work focused on the role of small non-coding Y RNAs and the RNA-binding protein, YBX1, in intracellular...

Welcome to Delphine, new post-doc in the team!

Apr 7, 2025 | Polo group

Delphine joins the lab as a post-doctoral fellow. She completed her PhD at the Centre de Recherche en Cancérologie de Lyon (CRCL) under the supervision of Virginie Petrilli. Her doctoral work focused on the pro-inflammatory protein NLRP3, for which she highlighted a...

New research article on how chromatin marking governs DNA damage segregation in mitosis

Jan 16, 2025 | Polo group

In this paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis with potential consequences on daughter cell fate. Thus, we reveal that chromatin alterations impinge on genome stability not only by...

Welcome to Julia

Jan 13, 2025 | Polo group

Julia Roche Dupuy joined the lab for her second year Master’s internship. Julia Roche Dupuy Second year Master’s student À lire aussi New research article on how chromatin marking governs DNA damage segregation in mitosis Polo groupIn this paper, we...

Review on the chromatin-based regulation of genome maintenance

Jun 11, 2024 | Polo group, Publications

A review from our research group is out for publication in DNA Repair as part of the special issue “Cutting-Edge Perspectives in Genome Maintenance”. This review presents our current knowledge on the contribution of pre-existing and DNA damage-induced...

4th year PhD fellowships to Giulia and Margherita

May 30, 2024 | Polo group

Congratulations to Giulia Giacomini and Margherita Mori for obtaining 4th year PhD fellowships from the Fondation pour la Recherche Médicale (FRM) and la Ligue contre le Cancer. Giulia Giacomini (left) and Margherita Mori (right) © Eliane Petit À lire aussi 4th year...

EMBO Workshop “Chromatin dynamics and nuclear organization in genome maintenance”

Jan 27, 2024 | Polo group, Symposia and seminars

Sophie Polo is co-organizing the third edition of the EMBO Workshop “Chromatin dynamics and nuclear organization in genome maintenance”. © https://meetings.embo.org/event/24-chromatin-dynamics The workshop will take place in Leiden, Netherlands, from June...

New research article on the impact of histone oncomutations on genome maintenance

Jan 12, 2024 | Polo group, Publications

January 12th 2024: We have uncovered an altered DNA repair activity in H3.3 mutant pediatric high-grade glioma that fosters genome instability independently of previously described oncogenic pathways. Furthermore, we have identified a DNA repair enzyme that sustains...