DNA methylation in cancer

We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.

UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.

In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.

Read more

Professional afterwork – April 22, 2024

Professional afterwork – April 22, 2024

Do you know what else exists outside academia?Come to talk about it with our two guests on Monday, April 22, 2024, at 6.15 pm. Where? Epigenetics and Cell Fate Center (EDC)Université Paris Cité - 35 Rue Helene Brion 75013 Paris – Lamarck B building - room 391  ...

Manuel Muñoz seminar

Manuel Muñoz seminar

Wednesday, March 6, 2024, at 11:00 am Manuel Muñoz University of Buenos Aires-CONICET, ArgentinaInvited by Sophie Polo “RNA polymerase II abundance is controlled by DNA repair” The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Buffon...

Jean-Christophe Andrau seminar

Jean-Christophe Andrau seminar

Wednesday, February 28, 2024, at 11:00 amJean-Christophe Andrau IGMM, MontpellierInvited by Pierre-Antoine Defossez “Secondary DNA structures contribute to promoter activity as nucleosome exclusion modules” The seminar will take place in the Institut Jacques Monod...