DNA methylation in cancer
We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.
UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.
In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.
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Seminar Adam SATERIALE –June 17, 2026
Dr. Adam Sateriale The Francis Crick Institute, London, UK Invited by Jonathan Weitzman and Marisol Giacomini "Intestinal parasites and metabolic mysteries." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Bâtiment Buffon, 15...
Seminar Laurent CHATRE –June 10, 2026
Dr. Laurent CHATRE STCT, UMR6030 CNRS, Université de Caen Normandie, France Invited by Dr. Dounia DJEGHLOUL "Reframing Epigenetics: Metabolism, Mitochondria, and Redox as Core Regulatory Layers" The seminar will take place in the Institut Jacques Monod seminar...
Seminar Michael Rera –June 3, 2026
Dr. Michael Rera Department of Functional and Adaptive Biology, Université Paris Cité, France Invited by Dr. Valerie Mezger "Studying ageing as a two-phase process." The hallmarks of aging framework, introduced over a decade ago and cited nearly 20,000 times, became...
Seminar Anne-Sophie Lebre– May 27, 2026
Pr. Anne-Sophie Lebre CHU de Reims - Hôpital Robert Debré, France Invited by Pr. Bertrand Cosson "Brain (epi)genome study in CNS rare disorders" The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Bâtiment Buffon, 15 rue Hélène Brion,...