January 12th 2024: We have uncovered an altered DNA repair activity in H3.3 mutant pediatric high-grade glioma that fosters genome instability independently of previously described oncogenic pathways. Furthermore, we have identified a DNA repair enzyme that sustains the proliferation of cells bearing H3.3 mutations, thus conferring a specific molecular vulnerability with potential for therapeutic targeting. We thank all our collaborators on this work for their great contributions. See Giacomini et al., Nucleic Acids Res, 2024.
À lire aussi
Welcome to Orlane
Today, we welcome a new member to the team: Orlane. She's a student from the first year of the Brevet de Technicien Supérieur Biotechnologies en Recherche et Production (Two-year technical degree - Biotechnologies in Research and Production).Orlane will be working...
4th year PhD fellowships for Anaëlle
Congratulations to Anaëlle Azogui for obtaining a 4th year PhD fellowships from the "Fondation pour la recherche sur le cancer" (Fondation ARC). Read more
Congratulations to the Defossez team for their article published in Nature Communication
Congratulations to the Defossez team for their article “DNA methylation protects cancer cells against senescence” by Chen, Yamaguchi, et al., which has been accepted in Nature Communication. Read it here: doi:doi: https://doi.org/10.1101/2024.08.23.609297...
Welcome to Delphine, new post-doc in the team!
Delphine joins the lab as a post-doctoral fellow. She completed her PhD at the Centre de Recherche en Cancérologie de Lyon (CRCL) under the supervision of Virginie Petrilli. Her doctoral work focused on the pro-inflammatory protein NLRP3, for which she highlighted a...