January 12th 2024: We have uncovered an altered DNA repair activity in H3.3 mutant pediatric high-grade glioma that fosters genome instability independently of previously described oncogenic pathways. Furthermore, we have identified a DNA repair enzyme that sustains the proliferation of cells bearing H3.3 mutations, thus conferring a specific molecular vulnerability with potential for therapeutic targeting. We thank all our collaborators on this work for their great contributions. See Giacomini et al., Nucleic Acids Res, 2024.
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