January 12th 2024: We have uncovered an altered DNA repair activity in H3.3 mutant pediatric high-grade glioma that fosters genome instability independently of previously described oncogenic pathways. Furthermore, we have identified a DNA repair enzyme that sustains the proliferation of cells bearing H3.3 mutations, thus conferring a specific molecular vulnerability with potential for therapeutic targeting. We thank all our collaborators on this work for their great contributions. See Giacomini et al., Nucleic Acids Res, 2024.

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Welcome to Léa, new engineer in the team!

Welcome to Léa, new engineer in the team!

Léa joins the lab as a research assistant. She holds a Master's degree in Molecular and Cellular Biology from Sorbonne University. She will contribute to investigate DNA methylation maintenance mechanisms in response to UV damage in mammalian cells. Léa Girard À lire...

Well done, Dr Mori!

Well done, Dr Mori!

Margherita successfully defended her PhD on DNA methylation maintenance in response to UV damage. Brava! Margherita and her thesis jury. From left to right: Sophie Polo, Sandra Duharcourt (on screen), Déborah Bourc'his, Margherita Mori, Nataliya Petryk, Jean Molinier,...

Congratulations Dr Giacomini!

Congratulations Dr Giacomini!

Giulia defended her PhD on the impact of high grade glioma-associated histone H3 mutations on genome integrity. Congratulations to her on a fantastic thesis defense! Giulia Giacomini and her thesis jury. From left to right: Beatrice Rondinelli, Keith Caldecott,...