Agathe Subtil seminar – June 7, 2023

Agathe Subtil

CNRS UMR3691, Institut Pasteur, Paris
Invited by Slimane Ait-Si-Ali and Sophie Polo

“Imprint of Chlamydia infection on the metabolism and epigenome of epithelial host cells”

The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Buffon building, 15 rue Hélène Brion, Paris 13th.

Zoom link for remote attendees:
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09

Contact: sophie.polo@univ-paris-diderot.fr

Relevant publications from the speaker:

Sequestration of host metabolism by an intracellular pathogen.
Gehre L, Gorgette O, Perrinet S, Prevost MC, Ducatez M, Giebel AM, Nelson DE, Ball SG, Subtil A.Elife. 2016 Mar 16;5:e12552. doi: 10.7554/eLife.12552.

Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells.
Maffei B, Laverrière M, Wu Y, Triboulet S, Perrinet S, Duchateau M, Matondo M, Hollis RL, Gourley C, Rupp J, Keillor JW, Subtil A. EMBO J. 2020 Apr 15;39(8):e102166. doi: 10.15252/embj.2019102166. Epub 2020 Mar 5.

Chlamydia trachomatis development requires both host glycolysis and oxidative phosphorylation but has only minor effects on these pathways.
N’Gadjaga MD, Perrinet S, Connor MG, Bertolin G, Millot GA, Subtil A. J Biol Chem. 2022 Sep;298(9):102338. doi: 10.1016/j.jbc.2022.102338. Epub 2022 Aug 2.