Monday, December 4, 2023, at 10:00 am
Thomas Graf
CRG, Barcelona
Invited by Pierre-Antoine Defossez
“Mechanisms of cell fate conversions”
The seminar will take place on Zoom only:
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09
Contact: sophie.polo@univ-paris-diderot.fr
Relevant publications from the speaker:
Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.
Torcal Garcia G, Kowenz-Leutz E, Tian TV, Klonizakis A, Lerner J, De Andres-Aguayo L, Sapozhnikova V, Berenguer C, Carmona MP, Casadesus MV, Bulteau R, Francesconi M, Peiro S, Mertins P, Zaret K, Leutz A, Graf T. Elife. 2023 Jun 27;12:e83951. doi: 10.7554/eLife.83951.
CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response.
Stik G, Vidal E, Barrero M, Cuartero S, Vila-Casadesús M, Mendieta-Esteban J, Tian TV, Choi J, Berenguer C, Abad A, Borsari B, le Dily F, Cramer P, Marti-Renom MA, Stadhouders R, Graf T. Nat Genet. 2020 Jul;52(7):655-661. doi: 10.1038/s41588-020-0643-0.
The transcription factor code: a beacon for histone methyltransferase docking.
Torcal Garcia G, Graf T. Trends Cell Biol. 2021 Oct;31(10):792-800. doi: 10.1016/j.tcb.2021.04.001.
Transcription factors and 3D genome conformation in cell-fate decisions.
Stadhouders R, Filion GJ, Graf T. Nature. 2019 May;569(7756):345-354. doi: 10.1038/s41586-019-1182-7.
Whsc1 links pluripotency exit with mesendoderm specification.
Tian TV, Di Stefano B, Stik G, Vila-Casadesús M, Sardina JL, Vidal E, Dasti A, Segura-Morales C, De Andrés-Aguayo L, Gómez A, Goldmann J, Jaenisch R, Graf T. Nat Cell Biol. 2019 Jul;21(7):824-834. doi: 10.1038/s41556-019-0342-1.
Read more
Congratulations to the Defossez group for their review published in Médecine/Sciences
Congratulations to Matthieu, Raady and Pierre-antoine for their review "Demethylating DNA against cancer : towards new epigenetic therapeutic strategies without DNA damage" published in Médecine/Sciences in february 2026! Read here
New research article on histone chaperones with central functions in chromatin repair
In this paper, we identify new players in chromatin repair through a novel approach for the proteomic profiling of DNA repair patches in human cells. Thus, we expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a...
Welcome to Léa
Léa joins the team as a research assistant. After completing a master's degree in virology, she worked in Strasbourg on grapevine viruses, then on characterizing mRNA degradation in plants at the Institute of Plant Molecular Biology (IBMP). In the Polo team, Léa will...
Sophie Polo receives an Impulscience® grant from the Fondation Bettencourt Schueller
Sophie Polo has been awarded an Impulscience® grant to fund a research project on the establishment and maintenance of the inactive X chromosome in response to DNA breaks. This is wonderful news for the lab ! We thank the Fondation Bettencourt Schueller for their...