The discovery that long noncoding RNAs (lncRNAs) are the most abundant gene class in the human genome has sparked significant research, particularly on Xist, a key RNA involved in X-chromosome inactivation. Recent studies have expanded our understanding of Xist’s molecular mechanisms, revealing novel and unconventional functions of its ribonucleoprotein (RNP) complex in gene silencing.
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Congratulations to the Defossez group for their review published in Médecine/Sciences
Congratulations to Matthieu, Raady and Pierre-antoine for their review "Demethylating DNA against cancer : towards new epigenetic therapeutic strategies without DNA damage" published in Médecine/Sciences in february 2026! Read here
New research article on histone chaperones with central functions in chromatin repair
In this paper, we identify new players in chromatin repair through a novel approach for the proteomic profiling of DNA repair patches in human cells. Thus, we expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a...
Welcome to Léa
Léa joins the team as a research assistant. After completing a master's degree in virology, she worked in Strasbourg on grapevine viruses, then on characterizing mRNA degradation in plants at the Institute of Plant Molecular Biology (IBMP). In the Polo team, Léa will...
Sophie Polo receives an Impulscience® grant from the Fondation Bettencourt Schueller
Sophie Polo has been awarded an Impulscience® grant to fund a research project on the establishment and maintenance of the inactive X chromosome in response to DNA breaks. This is wonderful news for the lab ! We thank the Fondation Bettencourt Schueller for their...