The discovery that long noncoding RNAs (lncRNAs) are the most abundant gene class in the human genome has sparked significant research, particularly on Xist, a key RNA involved in X-chromosome inactivation. Recent studies have expanded our understanding of Xist’s molecular mechanisms, revealing novel and unconventional functions of its ribonucleoprotein (RNP) complex in gene silencing.
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New research article on how chromatin marking governs DNA damage segregation in mitosis
In this paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis with potential consequences on daughter cell fate. Thus, we reveal that chromatin alterations impinge on genome stability not only by...
Welcome to Julia
Julia Roche Dupuy joined the lab for her second year Master's internship. Julia Roche Dupuy Second year Master's student À lire aussi
Welcome Caroline to our team!
We're excited to have Caroline joining Dr. Ait-si-Ali's team! She comes to us as an M2 student from the GENE2 master's program at Université Paris-Saclay. Working with Dr. Guillaume Velasco, Caroline will study the regulation of nuclear stiffness by H3K9...
Welcome Minh to Slimane Ait-si-ali’s team!
We are delighted to welcome Mynh, an M2 student from the GENE2 master's program at Université Paris-Saclay, to Dr. Ait-si-Ali's team. Mynh will be investigating the role of SETDB1 in Duchenne muscular dystrophy phenotype development.