New collaborative paper accepted in Scientific Reports for the Defossez group

Congratulations to Laure and Pierre-Antoine for their collaborative paper accepted in Scientific Reports:

“Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1”

Bhandari SK, Wiest N, Sallmyr A, Du R, Ferry L, Defossez PA, and Tomkinson AE
Sci Rep 13, 4363 (2023). https://doi.org/10.1038/s41598-023-31367-4

Congratulations to the Defossez team for their article published in Nature Communication

Defossez group, Epigenetics & Cell Fate, Publications

Congratulations to the Defossez team for their article “DNA methylation protects cancer cells against senescence” by Chen, Yamaguchi, et al., which has been accepted in Nature Communication. Read it here: doi:doi: https://doi.org/10.1101/2024.08.23.609297...

Welcome to Delphine, new post-doc in the team!

Polo group

Delphine joins the lab as a post-doctoral fellow. She completed her PhD at the Centre de Recherche en Cancérologie de Lyon (CRCL) under the supervision of Virginie Petrilli. Her doctoral work focused on the pro-inflammatory protein NLRP3, for which she highlighted a...

New research article on how chromatin marking governs DNA damage segregation in mitosis

Polo group

In this paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis with potential consequences on daughter cell fate. Thus, we reveal that chromatin alterations impinge on genome stability not only by...