Dr. Laure Bally-Cuif
Institut Pasteur and CNRS, Paris, France
Invited by Dr. Valérie Mezger
“Making sense of adult Neural Stem Cell heterogeneities“
The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).
Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th.
On Wednesday, January 28that 11:00 am.
Neural stem cell (NSC) populations ensure the production of neurons and astroglial cells in the vertebrate adult brain. NSC activity persists at long-term in zebrafish, but exhausts rapidly in mouse from the young adult stage. Using long-term genetic clonal tracing and intravital imaging in the zebrafish adult pallium (dorsal telencephalon), we revealed that two distinct NSC sub-populations cooperate to ensure population maintenance and neurogenesis. These sub-populations are endowed with self-renewal vs neurogenesis capacity and are organized in a functional hierarchy. Using sc-omics, we and others observed that these sub-population are themselves molecularly heterogeneous. The biological significance and regulation of these heterogeneities are unknown, as well as how they remain balanced in time and space over a lifetime. I will show our latest results on these questions, showing how we are taking in situ approaches and readouts of Notch3 signaling to decipher individual NSC trajectories and their coordination within the transcriptomic and physical spaces.
Antoine Zalc seminar – November 23, 2022
Wednesday November 23th, 2022, at 11:00 am Antoine Zalc Cell fate plasticity and reprogramming, Institut Cochin, Université Paris CitéInvited by Jonathan Weitzman “Reactivation of cranial neural crest cells pluripotency programs: a crucial path in development and...
Elena Brivio seminar – November 17, 2022
Thursday November 17th, 2022, at 10:45 am Elena Brivio Weizmann Institute of Science, IsraelInvited by Valérie Mezger “Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus” The seminar will take place in the Institut...
Jonathan Weitzman receives the Roy-Vaucouloux Prize
On October 18 and 22, the Académie des Sciences honoured 78 research actors for their talent and remarkable contributions to science. Jonathan Weitzman is one of them. © Académie des sciences The Academy of Sciences awards nearly 80 prizes each year, covering all...
Scientific symposium “Methylation signaling: Beyond histones and chromatin”
Protein methylation is emerging as a critical post-translational modification in signaling and cellular processes. New experimental approaches reveal that a large number of proteins are methylated and there is an emerging interest in the role of methylation of lysine...
Kathleen Stewart-Morgan seminar- September 28, 2022
Wednesday September 28th at 11:00 am Dr Kathleen Stewart-Morgan The Novo Nordisk Foundation Center for Protein Research, CopenhagenInvited by Sophie Polo and Nataliya Petryk “Quantifying propagation of DNA methylation and hydroxymethylation with EDIMS” The seminar...
Frédéric Berger seminar- September 21, 2022
Wednesday September 21st, 2022, at 11:00 am Frédéric Berger Austrian Academy of Sciences, ViennaInvited by Pierre-Antoine Defossez “When mothers take full control of embryo development: paternal chromosome repression in viviparous species” The seminar will take place...
Adrian Bird seminar – September 14, 2022
Wednesday September 14th, 2022, at 11:00 am Adrian Bird Wellcome Centre for Cell Biology, University of Edinburgh, UKInvited by Pierre-Antoine Defossez “Proteins that interpret genomic signals to stabilise cell identity” The seminar will take place in the Institut...
Welcome to Camille
June 27th 2022: Camille joined the group as a new research assistant to work on the Labex transverse project on intestinal organoids with Delphine Delacour (Jacques Monod Institute), Nicolas Minc (Jacques Monod Institute) and Béatrice Romagnolo teams (Cochin...
Group retreat
June 15th 2022: We had a fantastic group retreat in beautiful and sunny Aix-en-Provence! Warm thanks to all group members for their active participation and enthusiasm and to "Mas de Fauchon" for being wonderful hosts. The lunch under the fig tree was simply...