Wednesday, April 24, 2024, at 11:00 am.
Laetitia Aubry
Université d’Evry / I-Stem
Invited by Valérie Drouet
“Harnessing pluripotent stem cells derivatives from patients with Wolfram syndrome to reveal pathological mechanisms and identify potential therapeutic chemical compounds”
The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Buffon building, 15 rue Hélène Brion, Paris 13th.
Zoom link for remote attendees:
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09
Meeting ID: 861 1442 2072
Secret code: 492809
Contact: sophie.polo@univ-paris-diderot.fr
Relevant publications from the speaker:
Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome.
Zatyka M, Rosenstock TR, Sun C, Palhegyi AM, Hughes GW, Lara-Reyna S, Astuti D, di Maio A, Sciauvaud A, Korsgen ME, Stanulovic V, Kocak G, Rak M, Pourtoy-Brasselet S, Winter K, Varga T, Jarrige M, Polvèche H, Correia J, Frickel EM, Hoogenkamp M, Ward DG, Aubry L, Barrett T, Sarkar S. Stem Cell Reports. 2023 May 9;18(5):1090-1106. doi: 10.1016/j.stemcr.2023.04.002.
Human iPSC-derived neurons reveal early developmental alteration of neurite outgrowth in the late-occurring neurodegenerative Wolfram syndrome.
Pourtoy-Brasselet S, Sciauvaud A, Boza-Moran MG, Cailleret M, Jarrige M, Polvèche H, Polentes J, Chevet E, Martinat C, Peschanski M, Aubry L. Am J Hum Genet. 2021 Nov 4;108(11):2171-2185. doi: 10.1016/j.ajhg.2021.10.001.
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