DNA methylation in cancer
We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.
UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.
In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.
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Seminar Eugene Gladyshev –November 18, 2026
Dr. Eugene Gladyshev Molecular Genetics and Epigenetics Unit, Department of Mycology, Institut Pasteur "Homology-dependent initiation of gene silencing in N.crassa is mediated by ATRX/SAD-6." Abstract: Our group studies several genome-defense processes in the fungus...
Seminar Alex de Mendoza – October 21, 2026
Dr. Alex de Mendoza Center for Epigenetics, Queen Mary University of London, UK Invited by Dr. Pierre-Antoine Defossez "Tracing the Evolution of DNA Methylation Mechanisms across the Eukaryotes" The seminar will take place on Wednesday, October 21st at 11:00 am. Zoom...
Seminar Jan Padeken –October 14, 2026
Dr. Jan Padeken Institute of Molecular Biology, Mainz, Germany "UV-Damage-induced Epigenetic Memory in Organismal Resilience and Aging." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th....
Seminar Philipp Voigt –October 7, 2026
Dr. Philipp Voigt Babraham Institute, Cambridge, UK "Decoding bivalency: Mechanisms of poising at developmental gene promoters." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th. On...