DNA methylation in cancer
We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.
UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.
In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.
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Call for new Research Group Leader
The CNRS is launching a call for applications for a Junior Professor Chair (Chaire de Professeur Junior, CPJ) entitled “Epigenetics of Cellular Fate (EpiDeC)”, hosted at our Centre. All details in this document.
Sophie Polo elected EMBO member
Honored to be part of this prestigious scientific community. Sophie Polo in her laboratory © Romain Redler / Art in research for the Fondation Bettencourt Schueller À lire aussi
New research article on the role of SETDB1 in regulating inflammation and fibrosis in Duchenne muscular dystrophy
In this paper, we show that SETDB1 regulates the TGFβ-induced secretome and identify EMILIN1, an extracellular matrix protein, as a novel player in this process. EMILIN1 is overexpressed in muscle biopsies from DMD patients and influences both myogenic differentiation...
Seminar Benoît MOINDROT –July 8, 2026
Dr. Benoît MOINDROT The Institute for Integrative Biology of the Cell (I2BC), University Paris-Saclay Invited by Dr. Dounia DJEGHLOUL "One Genome, Two Voices: Decoding allelic chromatin-regulatory layers, and their perturbations, at imprinted domains." The seminar...