DNA methylation in cancer
We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.
UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.
In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.
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Theileria annulata and Cancer: a parasite strategy revealed!
Laetitia Aubry seminar – April 24, 2024
Wednesday, April 24, 2024, at 11:00 am. Laetitia Aubry Université d’Evry / I-StemInvited by Valérie Drouet “Harnessing pluripotent stem cells derivatives from patients with Wolfram syndrome to reveal pathological mechanisms and identify potential therapeutic chemical...
Moussa Benhamed seminar – April 17, 2024
Wednesday, April 17, 2024, at 11:00 am. Moussa Benhamed Institute of Plant Sciences, Paris SaclayInvited by Valérie Mezger “Exploring the chromatin-based regulation of enhancer-promoter contact and its impact on gene expression” The seminar will take place in the...
Professional afterwork – April 22, 2024
Do you know what else exists outside academia?Come to talk about it with our two guests on Monday, April 22, 2024, at 6.15 pm. Where? Epigenetics and Cell Fate Center (EDC)Université Paris Cité - 35 Rue Helene Brion 75013 Paris – Lamarck B building - Hall (Upper...