DNA methylation in cancer
We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.
UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.
In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.
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Congratulations to Dr. Silvia Comunian!
On September 25, 2026, Silvia successfully defended her thesis: “Epigenetic control of nuclear mechanics and migration via H3K9 methylation at Lamina-Associated Domains in lung cancer cells”Silvia Comunian and the jury members: Yegor Vassetzky, Nicolas Borghi,...
Welcome to Sara
Sara is joining the team for a master’s internship. As a student in the Interdisciplinary Master’s in Life Sciences program at the Ecole Normale Superieure, Sara will contribute to a research project aimed at identifying vulnerabilities in DNA repair in high-grade...
Seminar Cristiano SIMONE –September 30, 2026
Dr. Cristiano SIMONE University of Bari Aldo Moro, Bari, ItalyInvited by Dr. Souhila MEDJKANE "Unraveling SMYD3 functions along the Cancer Hallmark trail." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène...
Seminar Charles Williams –September 23, 2026
Dr. Charles Williams MRC Centre for Regenerative Medicine, The University of Edinburgh Invited by Dr. Dounia DJEGHLOUL "Mitotic bookmarking and chromatin regulation: from neural stem cell identity to brain tumour dependency." The seminar will take place in the...