Daniele Fachinetti seminar – January 11, 2023

Daniele Fachinetti

Institut Curie
Invited by Pierre-Antoine Defossez

“Centromere instability: causes and consequences”

The seminar will take place in the Institut Jacques Monod seminar room (RB-18B). Bâtiment Buffon, 15 rue Hélène Brion, Paris 13th.

Zoom link for remote attendees:
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09

Contact : sophie.polo@univ-paris-diderot.fr

Relevant publications from the speaker:
Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics.
Keizer VIP, Grosse-Holz S, Woringer M, Zambon L, Aizel K, Bongaerts M, Delille F, Kolar-Znika L, Scolari VF, Hoffmann S, Banigan EJ, Mirny LA, Dahan M, Fachinetti D*, Coulon A*.
Science. 2022 Jul 29;377(6605):489-495. doi: 10.1126/science.abi9810. Epub 2022 Jul 28.

Enrichment of centromeric DNA from human cells.
Gamba R, Mazzucco G, Wilhelm T, Velikovsky L, Salinas-Luypaert C, Chardon F, Picotto J, Bohec M, Baulande S, Doksani Y, Fachinetti D.
PLoS Genet. 2022 Jul 19;18(7):e1010306. doi: 10.1371/journal.pgen.1010306. eCollection 2022 Jul.

CENP-B-mediated DNA loops regulate activity and stability of human centromeres.
Chardon F, Japaridze A, Witt H, Velikovsky L, Chakraborty C, Wilhelm T, Dumont M, Yang W, Kikuti C, Gangnard S, Mace AS, Wuite G, Dekker C, Fachinetti D.
Mol Cell. 2022 May 5;82(9):1751-1767.e8. doi: 10.1016/j.molcel.2022.02.032. Epub 2022 Mar 22.

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy.
Giunta S, Hervé S, White RR, Wilhelm T, Dumont M, Scelfo A, Gamba R, Wong CK, Rancati G, Smogorzewska A, Funabiki H, Fachinetti D.
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2015634118. doi: 10.1073/pnas.2015634118.