In this paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis with potential consequences on daughter cell fate. Thus, we reveal that chromatin alterations impinge on genome stability not only by regulating DNA repair but also by controlling DNA damage segregation, which broadens the scope of genome maintenance mechanisms.
For more details, see Ferrand*, Dabin* et al., Nat Commun 2025.
Working model for how UV-damaged chromatin marking through alteration of mitotic histone phosphorylation controls the segregation of DNA damage in the cell progeny with consequences on daughter cell fate.
À lire aussi
Welcome to Delphine, new post-doc in the team!
Delphine joins the lab as a post-doctoral fellow. She completed her PhD at the Centre de Recherche en Cancérologie de Lyon (CRCL) under the supervision of Virginie Petrilli. Her doctoral work focused on the pro-inflammatory protein NLRP3, for which she highlighted a...
Welcome to Julia
Julia Roche Dupuy joined the lab for her second year Master's internship. Julia Roche Dupuy Second year Master's student À lire aussi
Welcome Caroline to our team!
We're excited to have Caroline joining Dr. Ait-si-Ali's team! She comes to us as an M2 student from the GENE2 master's program at Université Paris-Saclay. Working with Dr. Guillaume Velasco, Caroline will study the regulation of nuclear stiffness by H3K9...
Welcome Minh to Slimane Ait-si-ali’s team!
We are delighted to welcome Mynh, an M2 student from the GENE2 master's program at Université Paris-Saclay, to Dr. Ait-si-Ali's team. Mynh will be investigating the role of SETDB1 in Duchenne muscular dystrophy phenotype development.