In this paper, we identify new players in chromatin repair through a novel approach for the proteomic profiling of DNA repair patches in human cells. Thus, we expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a mechanistic coordination between old and new histone dynamics.
For more details, see Plessier*, Chansard*, Petit* et al., Nat Commun 2026.
Working model showing the histone chaperones DNAJC9 and MCM2 that are recruited to sites of UV damage repair and jointly coordinate old and new histone H3-H4 dynamics during chromatin repair.
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Sophie Polo receives an Impulscience® grant from the Fondation Bettencourt Schueller
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