Presentation
The “Epigenetics and Cell Fate” unit is a multidisciplinary research centre, founded in 2009, and located on the Grands Moulins campus of Université Paris Cité.
The research within the centre focuses on the importance of epigenetic regulations in the determination of cell fate and differentiation programs in mammals, under normal and pathological conditions.
Unit retreat in 2021
© Fabrice Ferron
The unit brings together six teams with complementary expertise in the molecular mechanisms of epigenetics (DNA methylation, histone variants and modifications, and non-coding RNAs), their involvement in development and differentiation processes, and their contribution to pathological processes.
Research in the unit is facilitated daily by a set of technical platforms and support services.
The unit is led by Dr. Slimane AIT-SI-ALI (director) and Dr. Pierre-Antoine DEFOSSEZ (deputy director). Together, they have established a managerial structure allowing the sharing of responsibilities and the delegation of tasks to the senior researchers of the unit. The Management Committee, which includes all the team leaders, makes the strategic decisions. The Lab Council, gathering the team leaders and elected members representing the different categories of personnel, discusses the general decisions concerning the centre’s functioning.
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Seminar Cristiano SIMONE –September 30, 2026
Dr. Cristiano SIMONE University of Bari Aldo Moro, Bari, ItalyInvited by Dr. Souhila MEDJKANE "Unraveling SMYD3 functions along the Cancer Hallmark trail." The seminar will take place in the Institut Jacques Monod seminar room (RB-18B).Bâtiment Buffon, 15 rue Hélène...
Seminar Charles Williams –September 23, 2026
Dr. Charles Williams MRC Centre for Regenerative Medicine, The University of Edinburgh Invited by Dr. Dounia DJEGHLOUL "Mitotic bookmarking and chromatin regulation: from neural stem cell identity to brain tumour dependency." The seminar will take place in the...
Seminar Laurent CHATRE –September 9, 2026
Dr. Laurent CHATRE ISTCT, UMR6030 CNRS, Université de Caen Normandie Invited by Dr. Dounia DJEGHLOUL "Reframing Epigenetics: Metabolism, Mitochondria, and Redox as Core Regulatory Layers." The seminar will take place in the Institut Jacques Monod seminar room...
Call for new Research Group Leader
The CNRS is launching a call for applications for a Junior Professor Chair (Chaire de Professeur Junior, CPJ) entitled “Epigenetics of Cellular Fate (EpiDeC)”, hosted at our Centre. All details in this document.