DNA methylation in cancer
We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.
UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.
In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.
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Welcome to Léa, new engineer in the team!
Léa joins the lab as a research assistant. She holds a Master's degree in Molecular and Cellular Biology from Sorbonne University. She will contribute to investigate DNA methylation maintenance mechanisms in response to UV damage in mammalian cells. Léa Girard À lire...
Well done, Dr Mori!
Margherita successfully defended her PhD on DNA methylation maintenance in response to UV damage. Brava! Margherita and her thesis jury. From left to right: Sophie Polo, Sandra Duharcourt (on screen), Déborah Bourc'his, Margherita Mori, Nataliya Petryk, Jean Molinier,...
Congratulations Dr Giacomini!
Giulia defended her PhD on the impact of high grade glioma-associated histone H3 mutations on genome integrity. Congratulations to her on a fantastic thesis defense! Giulia Giacomini and her thesis jury. From left to right: Beatrice Rondinelli, Keith Caldecott,...
Congratulations to Dr. Maeva Zamperoni!
On September 15, 2025, Maeva successfully defended her thesis: “Role of the lysine methyltransferase SETDB1 in TGFβ-induced fibrosis in Duchenne Muscular Dystrophy (DMD).”Maeva and the jury members: Pascal Maire, Nicolas Reynoird, Sestina Falcone, Frédérique...