DNA methylation in cancer
We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.
UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.
In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.
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Congratulations to Delphine and Julia for their research funding
Congratulations to Delphine Burlet on getting a postdoctoral grant from the Fondation de France and to Julia Roche Dupuy who obtained a fellowship from the HOB doctoral school to finance her PhD thesis. Delphine Burlet, Julia Roche Dupuy À lire aussi
Welcome to Annabelle, new post-doc in the team!
Annabelle joins the lab as a post-doctoral fellow. She completed her PhD at the University of Oxford under the supervision of Prof. Monika Gullerova. Her doctoral work focused on the role of small non-coding Y RNAs and the RNA-binding protein, YBX1, in intracellular...
Welcome to Orlane
Today, we welcome a new member to the team: Orlane. She's a student from the first year of the Brevet de Technicien Supérieur Biotechnologies en Recherche et Production (Two-year technical degree - Biotechnologies in Research and Production).Orlane will be working...
4th year PhD fellowships for Anaëlle
Congratulations to Anaëlle Azogui for obtaining a 4th year PhD fellowships from the "Fondation pour la recherche sur le cancer" (Fondation ARC). Read more