DNA methylation in cancer

We are actively investigating how abnormalities in the DNA methylation machinery contribute to transformation (see for instance Roussel-Gervais et al Cancer Res. 2017, Naciri et al NAR 2019). Projects that are currently ongoing use advanced genetics and genomics, such as degron alleles coupled with WGBS, and have the long-term goal of designing more efficient epigenetic therapies for cancer.

UHRF1 intensity at different timepoints before (left) and after (right) auxin addition in culture media.

In this cell line, the protein UHRF1 is fused to a green fluorescent protein (GFP) and can be degraded after auxin addition in culture media.

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Welcome to Delphine, new post-doc in the team!

Welcome to Delphine, new post-doc in the team!

Delphine joins the lab as a post-doctoral fellow. She completed her PhD at the Centre de Recherche en Cancérologie de Lyon (CRCL) under the supervision of Virginie Petrilli. Her doctoral work focused on the pro-inflammatory protein NLRP3, for which she highlighted a...

Welcome to Julia

Welcome to Julia

Julia Roche Dupuy joined the lab for her second year Master's internship. Julia Roche Dupuy Second year Master's student À lire aussi

Welcome Caroline to our team!

Welcome Caroline to our team!

We're excited to have Caroline joining Dr. Ait-si-Ali's team! She comes to us as an M2 student from the GENE2 master's program at Université Paris-Saclay. Working with Dr. Guillaume Velasco, Caroline will study the regulation of nuclear stiffness by H3K9...