Juliette did her PhD in Sophie’s lab working on histone variant dynamics in response to UV damage in human cells. She characterized the UV-induced mobilization of parental histones, which define the pre-damage chromatin state, and explored the impact of newly deposited histones on mitotic histone modifications at UV damage sites. After graduating in September 2018, she moved to the EMBL Epigenetics and Neurobiology Unit in Rome to work on cell-type specific target gene regulation in mammals, using the Olmsted Syndrome as a model to develop a CRISPR/Cas9-based approach for gene therapy. From January 2022, she has been back as a postdoctoral fellow in Sophie’s team to study chromatin dynamics in response to DNA double-strand breaks on the inactive X chromosome in mammals.
PUBLICATIONS
- Giacomini G., Piquet S., Chevallier O., Dabin J., Bai S-K., Kim B., Siddaway R., Raught B., Coyaud E., Shan C-M., Reid R.J.D., Toda T., Rothstein R., Barra V., Wilhelm T., Hamadat S., Bertin C., Crane A., Dubois F., Bandopadhayay P., Beroukhim R., Naim V., Jia S., Hawkins C., Rondinelli B.* and Polo S.E.*. Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors. Nucleic Acids Res, 2024. *: co-corresponding authors
- Dabin J.*, Mori M.*, Polo S.E. The DNA damage response in the chromatin context: a coordinated process. Curr Opin Cell Biol, 82: 102176, 2023. *: equal contribution
- Policarpi C., Dabin J., Hackett J.A. Epigenetic editing: Dissecting chromatin function in context. BioEssays, 43(5):2000316, 2021.
- Dabin J.*, Fortuny A.*, Piquet S., Polo S.E. Live imaging of parental histone variant dynamics in UVC-damages chromatin. Methods Mol Biol, 1832:243-253, 2017. *: equal contribution
- Adam S.*, Dabin J.*, Chevallier O., Leroy O., Baldeyron C., Corpet A., Lomonte P., Renaud O., Almouzni G., Polo SE. Real-time tracking of parental histones reveals their contribution to chromatin integrity following DNA damage. Mol Cell, 64(1):65-78, 2016. *: equal contribution
- Dabin J.*, Fortuny A.*, Polo S.E. Epigenome maintenance in response to DNA damage. Mol Cell, 62:712-727, 2016. *: equal contribution
- Adam S.*, Dabin J.*, Polo S.E. Chromatin plasticity in response to DNA damage: The shape of things to come. DNA repair, 32:120-126, 2015. *: equal contribution
- Adam A.*, Dabin J.*, Bai S.-K., Polo S.E. Imaging local deposition of newly synthesized histones in UVC-damaged chromatin. Methods Mol Biol, 1288:337-347, 2015. *: equal contribution