Delphine did her PhD at the Centre de Recherche en Cancérologie de Lyon (CRCL) under the supervision of Virginie Petrilli. Her doctoral work focused on the pro-inflammatory protein NLRP3, for which she highlighted a new role in the maintenance of genomic integrity, in connection with DNA repair mechanisms. Delphine joined the Polo group in April 2025 to characterize the role of repair proteins in pediatric gliomas haboring mutations in histone H3.
PUBLICATIONS
- Burlet, M. Khan, S. Hacot, L. Bardoulet, A-L. Huber, J. Gorry, Y. Couté, B. Lopez, A. Tissier and V. Petrilli, NLRP3 interaction with REV7 promotes genome integrity. Nucleic Acids Res, final revisions, 2025. https://www.biorxiv.org/content/10.1101/2024.11.28.625806v1
- Burlet, A.-L. Huber, A. Tissier, and V. Petrilli. Crosstalk between inflammasome sensors and DNA damage response pathways. FEBS J, 291: 3978-3988, 2024.
- Bodnar-Wachtel, A-L. Huber, J. Gorry, S. Hacot, D. Burlet, L. Gérossier, B. Guey, N. Goutagny, B. Bartosch, E. Ballot, J. Lecuelle, C. Truntzer, F. Ghiringhelli, BF. Py, Y. Couté, A. Ballesta, S. Lantuejoul S, J. Hall, A. Tissier, V. Petrilli. Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress. Life Sci Alliance, 6:e202201494, 2023.
- Moyret-Lalle, MK. Prodhomme, D. Burlet, A. Kashiwagi, V. Petrilli, A. Puisieux, H. Seimiya, A. Tissier. Role of EMT in the DNA damage response, double-strand break repair pathway choice and its implications in cancer treatment. Cancer Science, 113: 2214-2223, 2022.