Séminaire Yoichi Shinkai

Yoichi Shinkai

RIKEN Saitama, Japon
Invité par Pierre-Antoine Defossez

“Lysine methyltransferase EHMT1/GLP (Ehmt1) heterozygous KO mice as a Kleefstra syndrome model: challenging the onset mechanism and developing therapeutic strategies”

Le séminaire se tiendra à l’Institut Jacques Monod, salle François Jacob (RB-18B). Bâtiment Buffon, 15 rue Hélène Brion, Paris 13.

Lien Zoom pour les participants en distanciel :
https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09

Contact : sophie.polo@univ-paris-diderot.fr

Publications de l’intervenant :

Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome.
Yamada A, Hirasawa T, Nishimura K, Shimura C, Kogo N, Fukuda K, Kato M, Yokomori M, Hayashi T, Umeda M, Yoshimura M, Iwakura Y, Nikaido I, Itohara S, Shinkai Y. iScience. 2021 Jun 17;24(7):102741. doi: 10.1016/j.isci.2021.102741. eCollection 2021 Jul 23.

A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain.
Balan S, Iwayama Y, Ohnishi T, Fukuda M, Shirai A, Yamada A, Weirich S, Schuhmacher MK, Dileep KV, Endo T, Hisano Y, Kotoshiba K, Toyota T, Otowa T, Kuwabara H, Tochigi M, Watanabe A, Ohba H, Maekawa M, Toyoshima M, Sasaki T, Nakamura K, Tsujii M, Matsuzaki H, Zhang KYJ, Jeltsch A, Shinkai Y, Yoshikawa T.