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profil pic CastelGael

Gael Castel

Bioinformatician (CDD CNRS ERC XCycle)



Gaël performed his doctoral research on human trophoblast stem cells in the laboratory of Dr. Laurent David at the University of Nantes, where he graduated with a Ph.D. in Cell Biology.
During this period, he moved to Vienna, Austria, where he collaborated with the team of Dr. Nicolas Rivron, working on human blastoids. Involved in multi-omics analyses, he graduated with a university degree in integrative bioinformatics (DUBii 2021) from the University of Paris (now Paris City University).
He joined the Rougeulle lab as a research engineer in bioinformatics to address dosage compensation from a computational perspective.
He enjoys visiting the world and learning about foreign cultures.


  • Castel, G., Meistermann, D., Bretin, B., Firmin, J., Blin, J., Loubersac, S., Bruneau, A., Chevolleau, S., Kilens, S., Chariau, C., Gaignerie, A., Francheteau, Q., Kagawa, H., Charpentier, E., Flippe, L., François-Campion, V., Haider, S., Dietrich, B., Knöfler, M., … David, L. (2020). Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells. Cell Reports, 33(8), 108419. https://doi.org/10.1016/j.celrep.2020.108419
  • Kagawa, H., Javali, A., Khoei, H. H., Sommer, T. M., Sestini, G., Novatchkova, M., Scholte Op Reimer, Y., Castel, G., Bruneau, A., Maenhoudt, N., Lammers, J., Loubersac, S., Freour, T., Vankelecom, H., David, L., & Rivron, N. (2021). Human blastoids model blastocyst development and implantation. Nature. https://doi.org/10.1038/s41586-021-04267-8
  • Meistermann, D., Bruneau, A., Loubersac, S., Reignier, A., Firmin, J., François-Campion, V., Kilens, S., Lelièvre, Y., Lammers, J., Feyeux, M., Hulin, P., Nedellec, S., Bretin, B., Castel, G., Allègre, N., Covin, S., Bihouée, A., Soumillon, M., Mikkelsen, T., … David, L. (2021). Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification. Cell Stem Cell, 28(9), 1625-1640.e6. https://doi.org/10.1016/j.stem.2021.04.027